Since women headed households are considered as the vulnerable class of society due to reasons including: divorce, death, addiction and husband disablement, this study attempts to investigate socio-cultural factors influencing Tabriz women headed household and their ability degrees. The present research was a cross-sectional survey. Based on Cochran’s formula, the sample size was determined to be 288. The cluster sampling method helped to choose the sample members. The Questionnaires were distributed to collect required data and information. In this study, ability was measured from psychological, economic, social and political aspects. The validity of the data collection tool was ensured through a content validity and its reliability was tested through Cronbach's alpha. The finding of research showed that education, mass media, social support, physical health and food variables have positive and significant relationship with women households ability, however traditionalism and marital life condition has not significant relationship with the ability of women headed household. Multi regression results indicated that five variables including: mass media, health, social support, nutrition condition, and educational level have significant effect on ability degree and health plays the most important role among them in explaining the ability variable.