Globalization is nowadays fact. As production factors, World circulation of capital, goods and information has created new configuration of economic, social and spatial relations. In this condition, appearance of global cities, as the main center of establishing of new functions and connecting of national economy to global economy, is the most spatial outcome of globalization. In addition to support of establishing and renewal of globalization's socioeconomics structures, this centers provide basis for functional and economic dynamics of local, regional and even national background. This means that the cities, especially metropolitan regions, need establishing positive link with changes of globalization and its necessities.In this relation, the reasoning is that one of agents of un-sustainability of Tehran metropolitan region is lack of positive relationship with globalization and world cities network in recent two decades. So, this paper analyzed the place of Tehran metropolitan region based on indicators of economic globalization and global cities. Results showed that Tehran metropolitan region has not entered into globalization process and is out of the world cities network, yet. So that, the index of foreign direct investment (years of 1372-1386) and foreign trade volume (years of 1378-1383), as two main components of economic globalization, and comparative comparing of them with some of other metropolitan regions, showed the few share of Tehran metropolitan region in globalization. Also, review of the results of world researches on global cities showed that the Tehran metropolitan region is out of the world cities network.