Today, regionalism is one of the requirements of foreign policy and shape according to the surrounding areas andSpecific potential of each country, the government towards regional strategies to specific guidelines. Countries are trying to use the regional role and capacities available, to increase their international power increase. Iran and Turkey as two important countries in the Middle East region in terms of certain conditions that are always looking to increase its regional role. Accordingly, the question of this study is that developments in Syria and Iraq, Iran and Turkey have what effect on regionalism? Based on these findings, opportunities, political, economic, ideological, economic and security challenges and strengthen regional policy of the Islamic Republic of Iran and Turkey following the developments in the region. It is worth noting that the thesis of the Copenhagen School regional security challenges and opportunities in the form of three interdependent components: security inte Definitions of interdependent. This research using descriptive analysis and data collection as well as a library of document.