Ghezel-uzan is a river from Chehel-cheshme-Kurdestan to Caspian sea, it joints to several rivers and then in south of Gilan they create Sefidrood river. And then raid Caspian sea. Effect of this river on two lake of dam, include lake of sefidrood dam and lake of shahriar in the end of eastern Azarbayjan zone, and so it's effect on the ecosystem of them is an important point. On the other hand it self as a lagoon is so important. In this research we use NSF water quality index, that shows results in five ranges (very bad, bad, medium, good and great). We use parameters pH, TS, phosphate, nitrates, BOD5, FC and turbidity, that were detected with standard methods in eight stations for two period of time, then we used NSF calculator for determine NSF amounts. Results show that in high water duration in second station water quality is bad, that turbidity and BOD5 are most important reasons of this occurrence, however other reasons are effective. In both reasons station one and two, and station eight in less water season, water quality indices are in range good, that again these parameters were most effective. So these parameters controlling, specially with rain water controlling and wastewater controlling, will be so useful. In high water season in station eight and in other station in both seasons water quality is medium, in nor season and non station water quality are not in ranges great and very bad. Almost results of high water season are better than other season. Also TS in both seasons is a reason of reducing amount of water quality, so, its controlling especially in raining will be necessary. As FC is effective on reducing water quality index, its possible that the river is polluted with domestic wastewaters, that needs to control.