To study Parasitic infections in pikes (Esox lucius linnaeus, 1785), 120 pikes were caught from 4 different stations of Anzali wetland (East, west, Central, Siakishim) by hoop net. Fish were transferred lively to aquaculture research center of inner waters in the water tankers equipped with oxygen capsule. The infection status, severity of infection, abundance and index of parasitic prevalence in pikes were investigated in this project. Fish were studied after bioassay according to common methods of autopsy during of 1 year from the fall of 1388 to the summer of 1389. In this study 10 following species parasites were recognized: 2 species of Crustaceaen (Argulus foliaceus and Lernaea cyprinicea), 2 species of Nematoda (Eustrongylides exises and Raphidascaris acus), 2 species of Monogenea termatoda ( Tetraonchus monenteron and Dactylogyrus sp), 1 species of Digenea termatoda (Diplostomum spathaceum), 1 species of Unicellular Tricodina sp, 1 species of Acanthocephala (Corynosoma strumosum) and 1 species of Plathyhelminthes (Rhipdocotyle illense) were separated from the Anzali wetland pikes. According to results, highest incidence (26.66%) was belonged to Eustrongylides exises and Lowest incidence (3.33%) was belonged to Tricodina sp, maximum average virulence (88.5 pieces) was belonged to Rhipdocotyle illense and minimum average virulence (1.75 pieces) was belonged to Lernaea cyprinicea, maximum average frequency (11.8 pieces) was belonged to Rhipdocotyle illense and minimum average frequency (0.09 pieces) was belonged to Argulus foliaceus, maximum parasites number amplitude (3-300 pieces) was belonged to Rhipdocotyle illense and minimum parasite number amplitude (1-3 pieces) was belonged to Argulus foliaceus and Lernaea cyprinicea. Results showed that parasitic infection in pikes were influenced by season and age of fish in the Anzali wetland but were not affected by genus of fish. It was for the first time that following parasite, Corynosoma Strumosum was reported in pike of anzali wetland in Iran.