Zahedan Journal of Research in Medical Sciences
Year:2017 | Volume:19 | Issue:10|Papers Count:5

Background: The roots and leaves of Arctium lappa (burdock) have been used for different therapeutic purposes, especially for diseases linked to chronic inflammation.Objectives: The present study was designed to evaluate and compare the immunomodulatory activities of root extract of burdock and leaves extract of burdockin vitro.Methods: In this experimental study, PHA- or LPS-stimulated splenocytes were treated with different concentrations of root or leaves extract of burdock and proliferation of splenocytes measured by MTT assay. The levels of IFN-and IL4 in the supernatants of PHAstimulated splenocytes determined using ELISA. We also studied the effects of root and leaves extract of burdock on Nitric Oxide production by LPS-stimulated macrophages using the Griess reagent. The data were analyzed by one-wayANOVA followed by Tukey’s post-test using GraphPad Prism software, version 5.0.Results: Our findings showed that both root and leaves extract of burdock have suppressive effects on LPS-stimulated splenocytes proliferation, IL-4 secretion from PHA-stimulated splenocytes, and NO production from LPS-stimulated macrophage and stimulatory effects on PHA-stimulated splenocytes proliferation, and IFN-secretion from PHA-stimulated splenocytes. Although both root and leaves extract of burdock had similar immunomodulatory effectsin vitro, stronger immunomodulatory effects seen in root extract of burdock.Conclusions: According to our results, we suggest that root of burdock is better option than leaves of burdock in modulation immune responses and inflammations.

This study is about a patient with a history of infertility and polycystic ovarian disease who was admitted with spotting and severe abdominal pain, There was one misdiagnosis about this patient and progesterone was prescribed for treating of threatened abortion, following transvaginal ultrasound, one heterogeneous echogenic mass with dimensions of 5.818 in the vicinity of the left ovary was reported in favor of ectopic pregnancy. The patient was hospitalized and treated with methotrexate with diagnosis of an ovarian ectopic pregnancy. Pregnant women with complaints of bleeding and spotting in early pregnancy should be evaluated in terms of ectopic pregnancy in addition of abortion and molar pregnancy. The aim of this study was to introduce a new case of misdiagnosed ovarian pregnancy instead of threatened abortion.

Background: Iron over load will be appearing in kidney following blood transfusion. Desferal as an iron chelator can be ended renal complication.Objectives: The aimof this study is evaluation the level of b2 microglobulin in b - Thalassemia major patients for followupproximal tubular damage.Methods: In this descriptive and analytic study 40 thalassemic patients who were treated by Desferal and 40 healthy subjects enrolled in this study randomly. For evaluation the proximal tubular damage in these groups, we measured the b -2 microglobin.Another variable such as: Ca, Mg, P and Urea of blood and K, Cr, protein and volume of urine 24 hours were measured. We compared these variables between two groups. And descriptive and analytic analyses were used.Results: The level of b 2 microglobulin had significant difference in both groups, also the level of Ca, K and b -2 Globin in serum and Cr, protein and urine volume in 24 houres had significant difference.Conclusions: The higher level of b 2microglobulin in Thalassemia major patient who were treated by Desferal, show the proximal tubular damage.

Background: Intestinal parasite infection is one of the major health problems in the world especially in the developing countries.Objectives: This study was an attempt to examine the prevalence of intestinal parasite infection in the day care centers in Gonbad-e Kavus.Methods: In this cross sectional study, 932 children were recruited from 45 day care centers in Gonbad-e Kavus in Iran, through a survey and their stool samples were examined using direct wet mount, formalin-ether concentration and Trichrome staining techniques.Also, scotch tape slides were microscopically analyzed. Data were analyzed using percentage, frequency and Chi-square test using SPSS ver.16. Odds Ratio was used show the effect size of socio-demographic variables on the rate of intestinal parasite infection.Results: The prevalence of intestinal parasite infections among the children was 26.6%. This study found a significant relationship between the children age, parent education and the place of residency with the rate of intestinal parasite infection (P<0.05). The children in rural areas were 1.55 times more likely than the children in urban areas to be infected with intestinal parasites (OR= 1.55). Moreover, the results of this study showed that an increase in parent’s education for one level decreased the risk of infection in their children by 6% (OR=0.94). Also, with a rise in the age of participants for a year, the risk of infection increased by 44% (OR= 1.44).Conclusions: Due to the high rate of intestinal parasite infections among children, parents and child care workers need to learn about the various means by which parasites can be transmitted in day care centers.

Placenta accrete refers to an abnormality of placental implantation in which the anchoring placental villi attached tomyometrium rather than decidua resulting in a morbidity adherent placenta. Placenta increta (chorionic villi penetrate into the myometrium) and placenta percreta (chorionic villi penetrate through the myometrium to the uterine serosa or adjacent organs) are related, but more severe, abnormalities of placental implantation. The pathogenesis is primarily attributed to defective decasualization of the implantation site. Placenta accreta has been recognized mostly in the third trimester however may also present in second trimester. It has very heavy, life-threatening hemorrhage to both the mother and fetus. The authors’ report a patient with two previous cesarean deliveries, who had been referred for pregnancy termination from Iranian legal medicine organization with 15 weeks of gestational age and placenta acctera. In this patient, uterus preservation and hysterectomy abortion was performed. The case totally lost 1500 cc blood and she was discharged from hospital two days later, with feeling of well- being. We have examined this patient after 1.5 months, she wasn’t vaginal bleeding and the uterus was in the pelvic and serum BHCG (with titer) was negative.