The oasis of khwarazm, having native rulers (called khwarazm shahs) and enjoying domestic independence, has always been politically a part of iran, but in begining 10th century, was dominated by arabshahids, a clan of descendant of juchi. They could so doing and founded khanate of khiva by emphasis on inheritance of them ancestor, nomadic force, deep-rooted of orthodox religion, to agree that religion theme with that belong to them. They, eventually, were being under protection to safawid state, that was try ing to hold territorial integrity of Iran. In begining 12th century, arabshaid rule were been declined, therefore ,numerous conditions and causes. Weakness of safawid state were prevented them to be activated in this event, and there after, were falled, too, in short time. Consequently, the political unity and domestic security of Iran ruined and so it raised competition for power among political leaders and military commandars from the four-corners of the country, up to, nadir shah could renewed political unity of country, after two decades.This article, after all, intends to not only have an eye upon the politic upheavals of khwarazm, in interval period, but to examine the efforts of nadir shah, on renewing dominance of Iran on khwarazm and reactions of rulers of that area, on this matter, or in more precise wording, development and the quality of the relationship between rulers of that area and afsharid dynasty.