In all of the history of Iran after Islam, governance and domination of the Safavid dynasty, in many ways, is the most important era of the history of Iran after Islam, such as revival the national sovereignty, development and growth of trade, effectiveness on international trade, religious freedom of other non-Irany muslim nations, integrity and solidarity in political structure, purposefulness of growing economic activities, securance of public security and long periods of governance era. except from factors that their total resultant, led to, formation, establishment and continuity of the Safavids dynasty, some clear and unclear factors frequently also advanced independence and domination of the Safavid to extinction, that among of kings premature death, empowerment, growing demand of Qizilbash and tribes and their affiliate forces, mismanagement and the lack of king power and the ruling system, territorial expansionism and the expectations of non-conventional competitor countries such as the Ottoman and Uzbeks. and some European governments and intervention of power competition instituations in country, were all factors in phases sometimes acute, prepared fall of the Safavid, and finally, certained and confirmed this destruction, the resultant of its factors set. This study has designed and developed to seeks the answer of this question that which is the Safavids vanishing preventing factors that on the other side also has been causes of their continuity and domination? And they what origin and cause had have? And approach of Shah Abbas 1, as most important king of this dynasty, what consequent had have his rationality and wisdom property to continuity or vanishing this dynasty? Certainly, mentioned the kings outlook, approach and practice in this process, particularly in the some distinct cases, has been a strategic and effectiveness factor and is reasonable and analyzable the recognizing and understanding of the aspects and its outcomes and consequences.