The use of salicylic acid in the nutrition of medicinal plants under moisture stress conditions has a considerable role in reducing the effects of water stress and improving plant yield. To this purpose, a factorial split plot experiment with three replications based on randomized complete block design was conducted at the Research Farm of Faculty of Agriculture, Zabol University, Iran during 2013-2014 cropping years. Drought stress consisted of three levels (irrigation at 90, normal, 60 and 40 percent of field capacity) as main factor, and salicylic acid spraying wiyh three levels (0, control, 2. 5 and 5 mM) and three cultivars (Isfahan, Hamedan and Nahavand) minor factors, respectively. The investigasted traits were plant height, number of umbels per plant, number of umbellate per umbel, number of seeds per umbellate, root length, number of lateral branches, stem diameter, fresh weight of plant, grain and final plant yield, 1000 seed weight, chlorophyll a, b, total chlorophyll, carotenoids, anthocyanins, soluble sugars and proline. The results showed that drought stress decreased the traits under study. Salicylic acid spray caused an increase in some parameters such as the final height of the stem, the number of umbels, number of seeds per umbellate, root length, fresh weight of plant, seed and plant yield, chlorophyll a, b, soluble sugars and proline. Given the results of trilateral interaction effects, the greatest yield of grain was obtained from 5 mM spraying and Isfahan cultivar under irrigation conditions of 90% of the field capacity. Considering trilateral effects, the best cultivar in terms of grain yield was Isfahan cultivar with 5 mM spraying under complete irrigation conditions.