In order to evaluating of genetic diversity of sesame genotypes, screening the drought – tolerance quantitative indexes, determining and introducing the drought – tolerance genotypes and also having the economical performance, 24 sesame genotypes including internal and external cultivars were studied in Jiroft in the agricultural year of 2008. The tested genotypes were cultured in two separate experiments (normal and stress, irrigation after 100 and 240 mm evaporation from the basin of class A, respectively) based on RBD in 4 repetitions. In this study, the properties such as length of shrub, number of accessory branches in each shrub, number of capsules in each shrub, number of seeds in each shrub, weight of 1000 seeds, seed performance and the percentage of oil for each genotypes were determined. By using the seed performance in the normal experiment (Yp) and stress (Ys), the drought – tolerance quantitative indexes including (TOL) Tolerance index, (MP) Mean productivity, (SSI) Stress susceptibility index, (GMP) Geometric mean productivity, (STI) Stress tolerance index, (HM) Harmonic mean and (CV) Correlation varieties, were evaluated. The obtained results have shown hat there is a meaningful difference between the different genotypes in the normal and stress conditions and also, by considering the genetic diversity, there was possibility for choosing the drought – tolerance genotypes. The genotypes of JL-13Darab 14 and TS-3, due to the high performance of seeds in the normal and stress conditions and also obtaining the suitable place in the drought – tolerance indexes such as STI, MP, GMP and HM, were accounted as the tolerant genotypes. Analyzing the correlation between performance in the normal and stress conditions and also the drought – tolerance indexes was shown that indices of MP, GMP, HM and STI are the suitable indices for screening the sesame genotypes. In according to the above performance and four indices in two conditions (normal and stress conditions), the best drought – tolerance genotypes of sesame were determined as the genotypes of JL-13 and Ts-3.