Plants are always subjected to various environmental adverse factors such as salinity, drought, high/low temperatures, heavy metal toxicity, waterlogging, UV-B radiation, and ozone. Abiotic stresses cause hampering in the growth, physiology, and yield of crops and thus, are an important challenge for crop production and food security. Various strategies have been proposed to improve crop production under stress conditions, but attempts to enhance yield under these conditions have been largely unsuccessful. However, in recent years, exogenous application of phytoprotectants such as osmoprotectants (like proline and Glycinebetaine), phytohormones (for instance Abscisic acid, Salicylic acid, Gibberellic acid, Jasmonic acid, Brassinosteroids, and polyamines), antioxidants (including Ascorbic acid, Glutathione, and Tocopherol), micro nutrients (like Iron and Zinc), and trace elements (including Selenium and Silicon) have been found effective in mitigating the stress-induced damage in plant. This strategy has gained considerable attention because of its high efficiency, feasibility, and cost and labor effectiveness. Moreover, exogenous phytoprotectants show acceptable capacity to enhance plants’ growth, yield, as well as stress tolerance under adverse environmental factors. Regarding the importance of the application of exogenous phytoprotectants under stress condition, this article provides a review of the major responses of plants to these components in the presence of growth restriction factors.