ARCHIVES OF IRANIAN MEDICINE
Year:2020 | Volume:23 | Issue:10|Papers Count:13

Background: Non-communicable diseases (NCDs) are the leading cause of death worldwide, with a disproportionally rising burden among low-and middle-income populations. While preventable risk factors highly contribute to this burden, populationbased studies assessing these factors and the health status of these populations, are scarce. Methods: The Khuzestan Comprehensive Health Study (KCHS)— a cross sectional study— was conducted between 2016-2019, including 30, 506 Iranians aged 20 to 65 years, from 27 counties of Khuzestan province, southwest of Iran. KCHS aimed to provide a comprehensive health overview by investigating the prevalence and risk factors of NCDs and psychological disorders, along with viral hepatitis as a common communicable disease. Upon registration, 15 mL of blood and anthropometric measurements were obtained from participants. Afterwards, several interviewer-administered questionnaires were completed to gather data on demographics, socioeconomic status, sleep quality, physical activity, lifestyle habits, nutrition, and medical history. Results: The mean ± SD age of participants was 41. 7 ± 11. 9 years. The majority were female (64. 3%), of the Arab ethnicity (49%), married (83%), and urban residents (73. 1%). About 70% had an educational level below high school diploma. Overall, 10. 8%, 5. 2%, and 2. 8% of participants had used cigarettes, hookah, and drugs at least once in their lifetime, respectively. While body mass index and serum cholesterol levels were higher in females, blood pressure was higher in males (P < 0. 001). Conclusion: KCHS assessed many aspects of health in the Khuzestan province. In addition to develop a biobank along with a comprehensive dataset, KCHS will serve as a valuable infrastructure for future research.

Background: The medical profession has always been an inspiration for human societies throughout its diverse history. This position and historical authority in the field of ethics has had a different and higher status, in such a way that many of the norms of general ethics and professional ethics, especially principles, such as trust, confidentiality and respect for human dignity, have been developed by medical professionals. Developing guidelines of general and professional ethics is one of the inherent duties of the Medical Council of the Islamic Republic of Iran (IRIMC) as a professional organization. In this regard, the Supreme Council of IRIMC has approved the “ Code of Ethics for Medical Professionals” and, in accordance with its legal authority, has annexed it to the disciplinary regulations of IRIMC. Methods: A draft document, the result of extensive literature review, was discussed in 27 expert panel meetings and after receiving and endorsing the stakeholders’ point of view, was approved by the IRIMC Supreme Council. Results: The first edition of “ Code of Ethics for Medical Professionals, Medical Council of Islamic Republic of Iran” was developed on July 6, 2017 by the Supreme Council of IRIMC. The guideline was set to take effect one year after its enactment. The first edition was revised and completed and final edition was adopted on August 9, 2018 by IRIMC in 13 chapters and 140 articles (original full text is available in the Supplementary file 1). Conclusion: According to the approved decision by the Supreme Council of IRIMC on May 10, 2018, the final edition takes effect as of October 7, 2018.

Background: The childhood period is considered to be the primary period for acquisition of the Helicobacter pylori. The high prevalence rates from developing countries are associated with gastric cancer. A decreasing trend of its prevalence has been reported from different parts of the world. Determining the prevalence rate could be important in choosing preventive strategies. This study aimed to determine the prevalence of H. pylori among a group of children from southern Iran to provide an update on the current status of the disease. Methods: This is a cross-sectional population-based study conducted in Shiraz, southern Iran, from January 2014 to December 2015. Four groups including neonates, children aged 6 months to 3 years, 10-and 15-year-old children were included. Multimonoclonal stool antibody test was used for diagnosis. Results: Among 436 participants, 24. 8% (95% CI: 20. 8– 29. 1) had a positive test for H. pylori: 25% in neonates (95% CI: 16. 2– 36. 1), 22% in children aged 6 months to 3 years (95% CI: 15. 2– 30. 2), 19. 5% in the 10-year-old (95% CI: 12. 3– 29. 4), and 29. 2% in 15-year-old children (95% CI: 21– 39). Sex, age, number of siblings, owning a pet, parents’ smoking status, parental education, residential area, birth weight, and feeding status were not found to be statistically significant predictors of H. pylori antigen positivity (P > 0. 05). Conclusion: The prevalence of H. pylori was estimated to be low in southern Iran in comparison with previous reports or other developing countries. Preventive strategies with respect to low prevalence rates may be considered in the childhood period.

Background: Blood-borne viruses (BBVs) are one of the most important public health concerns. South Khorasan has a long border with Afghanistan and concern has risen there about blood-borne oncogenic viral infections. The aim of the present study was to evaluate the prevalence and associated risk factors of human T-lymphotropic virus 1 (HTLV-1) and co-infections of BBVs in Birjand, Iran’ s eastern border. Methods: In this cross-sectional study, 3441 subjects were tested for sero-prevalence of HTLV-1 by ELISA. The data on demographic features, HTLV-1-related risk factors and other characteristics of the population were analyzed by Pearson chi-square and logistic regression tests. Finally, the co-infection of BBVs was evaluated in the study. Results: The prevalence of HTLV-1 was 0. 3% (95% CI: 0. 12– 0. 48). Notably, the sero-prevalence of HIV, hepatitis B virus (HBV), hepatitis D virus (HDV), and hepatitis C virus (HCV) in our previous studies was reported at 0%, 0. 2%, 1. 2% and 1. 6%, respectively. The results indicated that the occurrence of HTLV-1 infection was associated only with the history of hospitalization (odds ratio [OR]: 0. 27, 95% CI: 0. 07– 0. 97, with P = 0. 04). The co-infection of HBV with HCV was the most common (2. 35%), while a coinfection rate of 1. 17% was found for both HBV/HTLV-1 and HBV/HDV. Conclusion: Although a higher prevalence of the viruses was expected, it was close to the overall Iranian population. With respect to close relationship with an HTLV-1 endemic area (Mashhad and Neyshabour), the prevalence is very low; however, more attention is needed. Our findings reinforce the importance of increasing knowledge about BBV-related health risk behaviors to prevent the emergence of new cases, especially in low-risk populations.

Background: Until now, no laboratory test or test set can guarantee the diagnosis of multiple sclerosis (MS) at early disease stages, and the disease symptoms may interfere with many other disease conditions. Analyzing the expression of circulating miRNAs may provide a useful approach for early and differential MS diagnosis. The main objective is assessment of the potential of serum miR-23a, miR-155, and miR-572 to differentiate between MS and other neuroinflammatory diseases. Methods: Serum miRNAs were obtained from 37 MS patients and 25 healthy age-matched controls, along with patients with neuromyelitis optica spectrum disorder (NMOSD) [n = 13] and neuropsychiatric systemic lupus erythematosus (NPSLE) [n = 10]. miRNA expression levels were analyzed using real-time polymerase chain reaction (PCR) and pairwise comparisons were made to reveal the diagnostic/distinguishing potential of the analyzed miRNAs. Results: In the study cohort, the three investigated miRNAs failed to display significant dysregulation in MS patients. However, they could significantly discriminate patients with NMOSD and NPSLE [median (IQR): 8. 1 (6. 1– 9. 2) and 8. 8 (7. 9– 9. 7) for miR-23a, 7. 5 (5. 3– 8. 3) and 8. 0 (7. 5– 9. 5) for miR-155 and 6. 9 (5. 0– 8. 8) and 6. 4 (5. 3– 8. 8) for miR-572 in NMOSD and NPSLE, respectively] from healthy subjects [median (IQR): 3. 4 (1. 5– 4. 3), 3. 1 (1. 1– 5. 6) and 3. 5 (1. 7– 5. 6) for miR-23a, miR-155 and miR-572, respectively], with area under the curve (AUC) ≤ 0. 8. Remarkably, miR-23a has been emerging as a prospective biomarker for differentiation of MS from NMOSD as well as NPSLE (AUC<0. 9). The miRNA combined use contributed to enhanced diagnostic and discriminatory performance in the study groups. Conclusion: Certain miRNA expression levels would contribute to discriminating MS from other neuroinflammatory diseases.

Background: Ankylosing spondylitis (AS; OMIM: 106300) is a common complex inflammatory disease; in a previous study, we introduced a novel mutation in the RELN gene (OMIM: 600514) which was associated with AS. This study is designed to investigate the potential effect of RELN S2486G mutation on reelin secretion; additionally, we objected to evaluate the phospholipase A2 (PLA2G7) gene (OMIM: 601690) expression and platelet-activating factor-acetylhydrolase (PAF-AH) concentration as the downstream gene and the encoded protein. Methods: The impact of the S2486G on reelin protein secretion was investigated in CHO-K1 and HEK-293T cells by constructing wild-type and mutant plasmids. Besides, the possible effect of the mutation on expression and concentration of PLA2G7 and PAF-AH in THP1 cells was assessed by quantitative real-time PCR (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA), respectively. The study was performed at Tarbiat Modares University, Tehran, Iran, from 2016 to 2018. Results: Our results showed that S2486G not only causes a significant reduction in reelin secretion in both HEK-293T and CHO-K1 cells, but also it leads to a significant reduction in PLA2G7 gene expression (P value < 0. 001) and protein level of PAFAH in THP-1 cells (P value < 0. 003). Conclusion: The S2486G mutation in RELN can alter inflammatory and, to some extent, osteogenesis pathways mediated by reduced secretion of reelin and also reduced expression of the PLA2G7 gene.

Background: Scientific journals will gain real credit when they meet publication ethics standards. This study seeks to evaluate the current status of medical journals’ adherence to some ethical standards. Methods: The 412 scientific journals approved by the Ministry of Health and Medical Education were included in this study. The process of downloading articles and data extraction for seven general and specific indicators related to publication ethics was conducted by trained researchers. Different methods were implemented by the team of colleagues to prevent possible errors in data extraction. After data integration, data analysis was performed using SPSS version 23. Results: Overall, 408 journals and 3948 articles met the inclusion criteria. The distribution of journals according to the highest journal index was 5. 4%, 13. 7%, 8. 3%, 8. 1% and 64. 5% for ISI, ESCI, PubMed, Scopus and Other indexes, respectively. In 27. 7% of the articles, the review process took over 6 months. According to the results, 6. 6% and 31. 7% of the articles belonged to the journals’ editors and owner universities, respectively. Journal self-citation was seen in 19. 2% of articles and in fewer than half of the articles (45. 5%), the status of conflict of interest was declared. In 36. 9% of the articles, the code of ethics or university ethics committee approval, and in 36. 5% of clinical trial articles, the clinical trial registration code was reported. Conclusion: Modifying processes or introducing new rules for indicators of publication ethics by trustee organizations can improve the current status. These seven indicators can also be used to rank journals.

Coronary artery fistulas (CAFs) are described as abnormal communications between a coronary artery and cardiac chambers, or other vascular structures. The two types of CAFs are defined as type I (singular fistula) and type II (microfistulas). Even though various electrocardiographic changes have been previously described in CAF patients, coronary-artery microfistulas causing STsegment elevation in diverse locations have not been reported. We describe a case report of an adult patient who presented with acute inferior myocardial infarction due to coronary-artery microfistulas. During the hospital stay, the patient re-experienced chest pain, and control electrocardiography revealed ST-segment elevation in the I and AVL leads along with reciprocal ST-segment depression in the inferior precordial leads. Although CAFs are clinically rare, they can have important clinical consequences. Microfistulas should be kept in mind as a cause of ST elevation myocardial infarction in some patients.

The honorable Abdul Hussein Tabatabaei was born in 1911 in Iran and received his medical education in the United Kingdom. Famously known as Dr. A. H. Taba, he was a well-respected man for his significant impact on the improvement of the national and global healthcare services and support for social justice. Before joining the World Health Organization (WHO), he was twice elected to the Iranian national assembly and served as the under-secretary of health services in Iran. Later, he joined the WHO and was elected as the Director of the Eastern Mediterranean Region (EMRO) in Alexandria in 1957 – a position he maintained for 25 years. During his tenure as the Regional Director, he rendered valuable assistance to the development and expansion of major health issues such as development and expansion of the health workforce, improvement of the national health services and controlling of various communicable diseases in the member countries and across the WHO regional offices.

Dear Editor, We read the publication on “ GSK3β Polymorphisms Are Associated with Tumor Site and TNM Stage in Colorectal Cancer (CRC)” with great interest. 1 Rosales-Reynoso et al. concluded that “ GSK3β gene polymorphisms play a significant role in promoting or preventing CRC” ...

The coronavirus associated disease 2019 (COVID-19) caused by the SARS-CoV-2 virus has rapidly spread all around the world and became pandemic in March 2020. Data on liver transplantation and chronic liver disease during the pandemic has remained scarce, and there is little information on whether immunosuppressed patients are at higher risk of developing severe COVID-19 infection. This review provides information for health care providers who care for patients with liver transplantation and chronic liver diseases.

Guillain– Barré syndrome (GBS) is a neurological disorder accompanied by several neurological signs and symptoms including progressive weakness and diminished or decreased reflexes. GBS was reported as one of the several neurological complications in MERS-CoV and SARS-CoV outbreaks. Several studies have reported GBS as a neurological complication in recent COVID-19 outbreak. We report on the case of a 55-years-old female who was hospitalized with dyspnea, dry cough, and myalgia. She developed Acute Motor & Sensory Axonal Neuropathy (AMSAN), a rare variant of GBS signs and symptoms including decreased muscle strength and pinprick sensation in both lower extremities during her hospitalization.

Dear Editor, We read with great interest the article by Taghrir et al 1 identifying the level of COVID-19-related knowledge and self-reported preventative behaviors and risk perception of Iranian medical students. From experience as medical students at Imperial College London, we too share the anxiety and uncertainty that our colleagues have expressed. Our knowledge and understanding of the issues surrounding the pandemic has been through the university’ s correspondence and the unremitting news reports we hear every day. 2 As a final year medical student and a researcher, respectively, we have identified some important factors that may implicate the study’ s validity which the authors may consider for future developments to this research...