In order to study the effect of Plant density on Some Quantitative and Qualitative Grain Yield of three Cultivars of durum wheat (Triticum durum) under Irrigation Condition, a field experiment was conducted in Mehran Agriculture research station of Ilam province during 2007-2008 year. Experiment was split plot desigh based on RCB (Randomized complet block) with four replications. factors were cultivars (Yavaros, Karkheh and Saymareh) and plant densities (300, 350, 400, 450 and 500 seed m-2). Therefor, effect of Plant density and cultivars on Yield and Yield components, Bilogical yield and harvest Index and Grain Protein Content were evaluated. Results showed that Cultivar and Plant density effects were significant (P>0.01) for Grain yield and harvest Index. Karkheh cultivar with 5859.87 (kg ha-1) and 46.07 (%) were highest Grain Yield and Harvest Index respectively. Saymareh cultivar with 490.37 (kg ha-1) and 40.74 (%) were lowest Grain Yield and Harvest Index respectively. Density of 450 seed m-2 with 5649.05 (kg ha-1) and 300 seed m-2 with 5043.27 (kg ha-1) were highest and lowest Grain Yield, respectively. Density of 500 seed m-2 with 44.70 (%) and 300 seed m-2 with 41.67 (%) were highest and lowest (HI), respectively. Effect of cultivar on Bioligical Yield is not Significant. There is Significant difference (P>0.01) of density related to Biological yield. The plant densities giving the highest (HI) were at least 400 to 500 seed m-2 for most the varieties studied. There is Significant difference of cultivars related to all of Yield Components. Results Showed that Karkheh cultivar have highest Spike no. per m2, Kernal no. per Spike, Spiklet no. per Spike and Kernal no. per Spiklet whith 601.68, 62.42, 18.32 and 2.26, respectively and Saymareh cultivar have lovest Spike no. per m2, Kernal no. per Spike, Spiklet no. per Spike and Kernal no. per Spiklet whith 530.75, 51.85, 15.19 and 1.57, respectively. The highest and lowest 1000-Grain Weight were related to Yavaros with 46.01 (g) and Saymareh with 40.63 (g), respectively. Effect of density on Yield Components were Significant (P>0.01). The highest Spike no. per m2, Kernal no. per Spike and Spiklet no. per Spike were related to 450 and 500 seed m-2, respectively; and lowest of these relevant to 300 seed m-2. The cultivar ´ density interaction effect on Grain Yield, Harvest Index, Kernal no. per Spike and Spiklet no. per Spike was Significant. Results Showed that Karkheh Cultivar at 400 seed m-2 with 6048 (kg ha-1), 46.8 (%) and 19.6 were gave the highest Grain Yield Harvest Index and Spiklet no. per respectively, and also highest Kernal no. per Spike was gave Kharkheh cultivar with 65.1 at 450 seed m-2. Grain Protein Content was significantly affected by cultivar and density. The highest Grain Protein Content were related to saymareh cultivar and 300 seed m-2.