Background: Results of using distraction osteogenesis has shown the importance of appliance orientation. Although successful results of mandibular lengthening using osteodistraction have been reported, optimal orientation of the distractors has not been determined accurately for mandible.Aim: The purpose of this study was to evaluate the biomechanical effects of unilateral distraction osteogenesis in mandible, using a finite element model.Materials & Methods: Three different osteotomy lines (ie: oblique, vertical, transverse) with three different pin angulation (30, - 60, -90) degrees were compared which were related to the osteotomy lines. Displacement of proximal, distal bony segments and Pog onion were precisely evaluated on this model.Results: Vertical osteotomy line (90 degree) caused the most displacement in all the osteotomy lines, except transverse line (90 degree), pogonion displaced upward. In vertical osteotomy lines angles changing from 90 to 60 and them 30 degreees displacement of pogonion reduced in all planes, but with ablique and transverseosteotomy lines, displacement of pogonion increased in all planes.Conclusions: Biomechanical principles must be applied in treatment planning for distraction osteogenesis of mandible. Determination of distractors, orientation and osteotomy lines must be included in preoperative planning for mandibular osteodistraction.