Introduction: Modern methods and telemonitoring manage care and control of chronic diseases has improved, meanwhile, the hospital uses traditional methods to teach their patients. Purpose of Study: The purpose of the study was to compare the effectiveness of three methods of follow-up (SMS, telephone and regular follow up) on the quality of life in heart failure patients. Methods: In the randomized clinical trial, patients with heart failure admitted to Emam Ali and Emam Reza hospitals were selected. The patients or dependent relatives of the patients had used mobile phones and text messages with a written consent participated in the study. With a convenience sampling the patients selected and patients randomly assigned to three groups of SMS, telephone and regular follow-up, respectively. Each patient was assessed before and in the first, second and third months after discharge, respectively. To collect data, the Minnesota Living with Heart Failure Questionnaire was used. The data were analyzed with software SPSS VER19 by paired t test, repeated measure ANOVA and curves. Finding: Twenty five patients assigned to each group. Therewere not statistically significant differences between the quality of life of the telephone follow up before and the first, second and third months, as well as in the regular follow-up (36± 12. 6, 41. 7± 14. 4, 36. 5± 13. 5 and 36± 13. 2, respectively) and also there wasn’ t significant difference between before discharge and after 3 months in regular follow up (38± 17 vs. 39. 7± 17. 7) In the follow up via SMS, there was a significant difference between the quality of life before and in the first, second and third months (49. 6± 21. 5, 43. 9± 16. 6, 39. 1± 13. 8 and 38. 4± 12. 6 respectively). Conclusion: Because the heart failure patients need different education and follow up, the result of this study showed that SMS follow up can promote the patients’ quality of life, but telephone and usual follow up didn’ t change the quality of change in heart failure patients. Hence, follow up by SMS may be considered in these patients.