Psycho security is one of the most vital requirements of the human life which make its preparation an inevitable necessity. This article concentrates on the concept of psycho security and its factors and impediments. The ideas of the religious leaders become very important in securing such environment. Thus, it concentrates on finding the factors and the obstacles of psycho security in the ideas and the thought of Grand Ayatollah Ali Khamenei. Using the content analysis method, analyzing his speeches since 1998 to 2013, and by categorization of the factors and the obstacles, the article present this hypothesis: “making distance of the Holy Quran, the lack of software progress in Islamic civilization, the shortness of belief in personal life, non-commitment of Islamic Shari’ a, the weakness of the Islamic nations toward its enemies, mere scientific nature of the universities, the lack of the good deed and creating the since of pessimism are among the most important obstacle of psycho security. On the opposite, the presence of factors such as harmony with Quran, Islamic life method, preparation of armed forces and … are the best solution for creating a milieu of psycho security.