JOURNAL OF INFLAMMATORY DISEASES
Year:2021 | Volume:24 | Issue:5 (112)|Papers Count:9

Background One of the complications of diabetes, as a chronic metabolic disorder, is cardiovascular diseases. Objective This study aims to investigate the effect of an eight-week High-Intensity Interval Training (HIIT) program on serum Cardiac troponin I (CtnI) level in streptozotocin-induced diabetic rats. Methods In this experimental clinical trial, 30 rats were randomly assigned into three groups of healthy Control (C), Diabetic (D), and diabetic+training (D+T). The third group performed the training which included a treadmill running at an intensity of 85%-90% of maximum speed in 6-12 sessions of 2 min for 8 weeks, 5 days per week. Blood glucose level and high-sensitive CtnI levels were measured 48 hours after the last training session and 12 hours of fasting. One-way ANOVA and Tukey’ s test were used to analyze the collected data, considering a significance level of P<0. 05. Findings The induction of diabetes caused a significant increase in blood glucose (P=0. 01) and high-sensitive CtnI (P=0. 01) levels in the D group. Also, a significant difference was observed in the blood glucose level of D+T group compared to the D group (P=0. 001). The CtnI level also slightly reduced (11%) in the D+T group compared to the D group, but it was not statistically significant (P=0. 591). Conclusion he HIIT program can reduce the fasting blood glucose and increase the serum level of highsensitive CtnI to some extent in diabetic rats; therefore, it can be an appropriate strategy for diabetics. However, there is a need for more studies in this area.

Background Recurrent Pregnancy Loss (RPL) is a multifactorial disease that affects 1%-3% of couples. Since Human Leukocyte Antigen-G (HLA-G) gene is involved in fetal maternal immune tolerance, mutations in the HLA-G gene can affect the success rate of pregnancy. Objective The present study aims to investigate the haplotype effect of rs1736933 and rs2735022 polymorphisms found in the HLA-G gene on the RPL. Methods In this case-control study, participants were 100 women with RPL and 80 women with normal fertility in northwestern Iran. The HLA-G gene promoter was amplified by Polymerase Chain Reaction (PCR) method and sequenced. The genotype and allele frequencies of the two polymorphisms were compared between the two groups by using t-test in SPSS software version 22. Haplotype analysis was performed using PHASE 2. 1 and Haploview 4. 2 applications Findings C allele and CC genotype in rs2735022 polymorphism and the G allele and GG genotype in rs1736933 polymorphism showed a significant association with the RPL (P<0. 05). Frequency of haplotypes AA, AC, GA, GC were 0. 72, 0. 23, 0. 01, 0. 03 in patients and 0. 39, 0. 01, 0. 02, 0. 59 in the control group (P<0. 05). The linkage disequilibrium score was 94. Conclusion Analysis of GC haplotype in rs2735022 and rs1736933 polymorphisms of the HLA-G gene can be helpful in genetic studies of women with RPL.

Background Due to the increasing life expectancy and aging population, attention to general health and marital satisfaction of older people can provide an opportunity to improve their living conditions. Objective This study aims to assess the general health indicators of older couples to predict their marital satisfaction. Methods This descriptive cross-sectional study was conducted on 110 older couples (men and women) living in Qazvin, Iran who were selected using two-stage cluster sampling technique. A demographic form, General Health Questionnaire (GHQ) and The ENRICH Marital Satisfaction Scale (EMSS) were used to collect data. Descriptive statistics and multivariate regression analysis were used for data analysis. Findings The Mean± SD age of older women and Men± SD was 64. 15± 5. 46 years and 67. 68± 6. 93 years, respectively. Their Mean± SD EMSS score was reported 109. 72± 12. 58. Multivariate analysis showed that gender (β =0. 169, P=0. 050), age (β =0. 097, P=0. 567), age of marriage (β =0. 214, P=0. 002), somatic symptoms (β =0. 233, P=0. 013), anxiety/insomnia (β =0. 227, P=0. 008), social dysfunction (β =0. 326, P<0. 001), and depression (β =0. 356, P<0. 001) could significantly predict marital satisfaction. Conclusion Different dimensions of general health can affect marital satisfaction of older couples. Therefore, interventions in these domains and the promotion of general health level can lead to increased marital satisfaction and, consequently, quality of life in the elderly.

Background Psychological problems such as death depression can have adverse effects on Emergency Medical Technicians (EMTs) including reduced quality of medical services, job dissatisfaction, feelings of incompetence, depression, and reduced job values. Objective This study aims to determine the factors predicting death depression of EMTs in Iran. Methods In this descriptive cross-sectional study conducted in 2019, participants were 125 eligible EMTs in hospitals affiliated to Qazvin University of Medical Sciences in Qazvin, Iran. Templer’ s Death Depression Scale (DDS) and a demographic form were used to collect data. The collected data were analyzed using descriptive and inferential statistics. Findings The Mean± SD DDS score was reported 4. 73± 2. 93. Most of subjects (n=79, 63. 2%) had low death depression. According to the results of linear regression analysis, “ number of resuscitation attempts in the last 3 months” , “ organizational position” and “ history of depression” were the predictors of death depression (P<0. 05). In total, the regression model predicts 9% of the variance in death depression. Conclusion Death depression of EMTs in Iran is low. Due to the importance of mental health in medical staff in providing quality clinical services, it is recommended that further studies should be conducted in this area using a larger sample size.

Background Preeclampsia is a complex disorder of pregnancy with an unknown etiology. Numerous studies have shown the possible role of gene polymorphisms, especially metalloproteinases, in development of this disease, but there are no definitive results. Objective This study aims to investigate the possible association between rs3918242 (− 1562C>T) polymorphism in Matrix Metalloproteinase 9 (MMP9) gene with the risk of preeclampsia in pregnant women. Methods In this cross-sectional study, participants were 90 pregnant women with preeclampsia and 199 healthy pregnant women (controls). The genotypes of rs3918242 polymorphism were investigated using Polymerase Chain Reaction technique and Limited Fragment Length Polymorphism method. Logistic regression analysis was used to investigate the relationship between rs3918242 polymorphism and preeclampsia. Findings The frequency of CC, CT, TT genotypes of rs3918242 polymorphism was reported 47. 8%, 47. 8% and 4. 2% in patients and 84. 8, 13. 1 and 2% in controls, respectively, and the difference between groups was significant (P<0. 001). The frequency of TT genotype in patients was significantly higher than in controls (P<0. 001). Moreover, the frequency of T allele in patients was 52. 2%, while in controls it was 15. 2% and the difference between the two groups was significant (P<0. 001). Conclusion The rs3918242 polymorphism of MMP9 gene plays an important role in the incidence of preeclampsia in pregnant women.

Background Despite the widespread obesity epidemic in the world, not all obese people are equally susceptible to the complications of obesity. Inflammatory factors play an important role in the complications of obesity. Objective This study aims to evaluate the association of White Blood Cell (WBC) count with metabolic syndrome in overweight/obese men and women. Methods This cross-sectional study is a part of the Qazvin Metabolic Disease Study (QMDS) conducted in 2010 in Qazvin, Iran. Participants were 622 obese people with a body mass index (BMI) ≥ 25 kg/m, recruited from the QMDS. Metabolic syndrome was defined according to the Adult Treatment Panel III criteria. Data were analyzed using Chi-square test, t-test, and logistic regression analysis (to evaluate the relationship between WBC count quartiles and metabolic syndrome). 2 Findings Prevalence of metabolic syndrome was not significantly different between men and women. In men, prevalence of metabolic syndrome and its components were not different between WBC quartiles. In women, 32. 2% and 60. 5% had metabolic syndrome in the first and fourth quartiles of WBC count, respectively (P<0. 001). Moreover, the prevalence of insulin resistance was higher in fourth quartile compared to the first quartile (47. 7% vs. 25. 6%, P<0. 001). After controlling the effects of age and BMI factors, the risk of metabolic syndrome in the fourth quartile of WBC count remained significant in women (OR=2. 56, P<0. 01). Conclusion Association of WBC count with metabolic syndrome is significant in obese women compared to obese men.

Background Optimal performance of health care tasks by the government in a way that promotes public health and development of the country is one of the most important pillars of governance. Objective This study aims to present an optimization model for performing health care tasks by the Iranian government. In this model, the optimal interaction of governmental actors at the three action levels of governance (individual, organizational, and systemic) is examined. Methods This is an applied descriptive study. Participants were 8 governmental management experts and 350 managers and deputies of the public, private, and non-governmental organizations in Iran. Data were collected by a researcher-made questionnaire. For designing the research model, fuzzy inference system was used. Findings Promoting health care at the individual, organizational, and systemic levels was effective in optimally performance of the health care tasks by the government. At the individual level, civil society had a more important role, while the private and public sectors had a more important at the organizational and systemic levels, respectively. Conclusion For optimal performance of macro-tasks in the field of health care, the Iranian government needs to pay more attention to the interaction of civil society and the private, public, and military sectors. Extended Abstract G 1. Introduction overnments face a wide range of tasks. It is important to discuss what the duties of a government are, because it can determine whether the task should be performed by the government or can be delegated to non-governmental actors [1]. The complicated responsibilities of the governments are defined by the concept of "Governance" [2]. It refers to a set of in

The mortality rate of Coronavirus Decease 2019 (COVID-19) is very high, but specific situations can in-crease the rate including severe hypoxemia, multiple organ injury, and thromboembolic events in various organs. Another factor is the stress caused after surgery that require general anesthesia. This study aims to report a case of death in an adult woman with COVID-19 infection who had underwent septoplasty and admitted to hospital after worsening of her general condition and treated when diagnosed with COVID-19. One day after admission, she was intubated due to progressive respiratory failure and deceased following bradycardia and cardiac arrest. It seems that the elective surgery should be avoided in patients infected with COVID-19 and should be postponed until complete recovery. Moreover, the possibility of this infection should be considered in all candidates for surgery with subtle respiratory symptoms.

Mammalian Target Of Rapamycine (mTOR) is a conserved serine/threonine kinase in the PI3K/Akt/ mTOR signaling pathway. This pathway is regulated by changes in cells such as change in energy level, growth factors, and stressful conditions as well as increased level of cytokines which cause cancer development. The increase in the function of this pathway has been observed in various types of human cancers, especially in cancer stem-like cells. The association of this pathway with the most common Central Nervous System (CNS) cancers such as glioblastoma, medulloblastomas and tuberous sclerosis complex is under investigation. Recent studies have examined the relationship of different cellular signaling pathways and genetic mutations in the CNS cancers with the mTOR pathway. Based on previous studies, different treatments such as surgery, chemotherapy, and radiotherapy are not effective and have some complications. Therefore, the researchers are trying to find new effective treatment methods for cancers. One approach is to have knowledge of all molecular pathways, proteins and genetic mutations related to cancers. This study aims to investigate the effect of mTOR signaling pathway on the CNS cancers. In this regard, after searching in Google Scholar, PubMed, Science Direct, and Scopus databases, 78 articles were selected for review.