In this essay, positivism is briefly introduced. Furthermore, Shariati’s opinion about positivists’ thought is expressed. In the first part, similarities between Shariati and positivism are probed. These similarities include scientific method, objectivity of natural science, accuracy and credibility of natural science and relying on it, utilization of natural science methods in human science and distinguishing between identification and judgment. In the second part, differences between Shariati and positivism are probed. These differences include role of culture in science, criticizing scientific abstinence and the idea of “science for science”, effect of individual and society on science (subjectivism), the difference between natural science and human science in accuracy and credibility, criticizing scientism, necessity of philosophy and metaphysics (refutation of empiricism) and science need to identify human correctly.At the end, we conclude that Shariati is not completely a positivist and also is not completely against positivists.