Within two recent decades, the complexity of business environment, dynamics, uncertainty and higher environmental fluctuations, concepts such as globalization and increasing competition made many changes in the equations ruling on the industries supply chain. In such conditions, the businesses must make themselves ready for encountering the continuous flow of challenges such as economic crises, sanctions, exchange rate and prices fluctuations, limitations of manufacturing system or natural disasters. “ Resiliency” is one of strategies for dealing with such challenges. The present study aims to review the studies based on the strategic position of pharmaceutical industry as a part of society’ s health system and present here the resilient supply chain model. For this purpose, in addition to contemplating in the literature review, interview to the experts and using Delphi method, the resilient elements and indices of supply chain were identified and extracted, and a questionnaire was designed and provided to the population of pharmaceutical industry. The results were analyzed using structural Equations modeling technique and Lisrel software, and the proposed model of research was accepted upon explaining the associations between factors. This model studied the relationship between elements such as drivers, vulnerabilities, capabilities and empowerments of supply chain and their effect on each other. Summary of study indicates that the managers of pharmaceutical industries through making or using the capabilities and strengthening the empowerments can reduce the factors that make the companies susceptible for the disruption, and achieve the required resiliency to deal with them.