Introduction: Enuresis is one of the most common disorders in children and its prevalence varies according to the living region and age. The aim of this study was to determine the prevalence of enuresis and its related factors in school-age children. Methods: This descriptive-analytical and cross-sectional study included 1465 school-age children in Bandar Abbas in 2015. A checklist was used for data collection including children’ s age, gender, educational status, history of urinary tract infection or upper respiratory infection, diurnal enuresis (presence and frequency), and snoring, as well as parents’ age, education, employment status, history of enuresis in parents and siblings, and the number of individuals sleeping in the same place as the child. Data were analyzed using SPSS software and Chi-square, Fisher's exact and independent T-tests. Results: Enuresis was observed in 79 children (5. 4%). Frequency of nocturnal enuresis, proportion of males, snoring, history of enuresis in parents or siblings, diurnal enuresis, treatment of enuresis, and number of mothers with higher than diploma education were significantly higher in children with enuresis compared to those without enuresis, while the mean age of children and their mothers and proportion of employed fathers were significantly higher in children without enuresis. Conclusion: Some variables including history of enuresis in parents or siblings, snoring, parents’ education, and employment of father are associated with enuresis which should be condidered in designing preventional programs.