Jundishapur Scientific Medical Journal
Year:2021 | Volume:20 | Issue:4|Papers Count:11

Background and Objectives: Internal Root Resorption (IRR) occurs in pulpchamber and canals of the toothand results in desolation of around dentin. Regarding to important role of early diagnosis of IRR in prognoseand treatment plan of the teeth and also limitations of intraoral technics in early detecting of theselesions, in this study we evaluated the accuracy of PSP in diagnosis of these lesions. Subjects and Methods: We split 70 single root premolar teeth mesiodistalyand made artificial IRR in 35teeth. The rest of them used as control group PSP and Conventional radiography captured from all teeth. IRR existence or not was considered in PSP and Conventionalradiographies of each tooth. Results: PSP has complete agreement in all cases with reality but Conventional radiography in some casesparticularly in 1/3 apical lesions of the root has moderate accuracy with reality and its results diden’, thave considerable differences with reality. Conclusion: Regarding to this study, has higher accuracy for PSP than Conventional radiography in detectingInternal root resorption lesions particularly in apical sites.

Background and Objectives: The aim of this present study is to review the effects of antibacterial propertiesof oak fruit, inner husk of oak fruit, and Jaftex mouthwash. Subjects and Methods: The present study is a narrative literature review conducted using electronic databasessuch as ISI, PubMed, Scopus, Google Scholar, SID, Magiran, and IranMedex from 1995 to 2019. The keywords that were searched included “, Oak fruit”, , “, Oak tree”, , “, Jaftex mouthwash”, , “, Antibacterial”, , “, Antimicrobial”, , and “, Microorganism”, . Results: Review of previous studies showed that oak fruit, Jaft, and Jaftex mouthwash have antimicrobialproperties against different microorganisms. Jaftex mouthwash significantly reduced number of microorganismsin mouth, however it had less antimicrobial effect compared to chlorhexidine. Jaftex had agreater inhibitory effect on bacterial growth than Matrica and Persica. Conclusion: Oak fruit and Jaft have antibacterial properties which is related to presence of phenols, tannin, proteins. Various studies confirmed antibacterial property of these types of plants. The antibacterial characteristicsof Jaftex mouthwash is mainly related to Jaft extract. Jaftex is recommended as an antibacterialmouthwash.

Background and Objectives: Optimal physical space and mental environment are the most important factorsin achieving the good level of educational quality. A healthy environment and a safety education play animportant role to prevent diseases and accidents. The aim of this study was to determine the safety andenvironmental health condition of Andika city schools and its comparison with national standards. Subjects and Methods: This is a descriptive cross-sectional study in which 40 schools from all Andika cityschools. In this study, first Raw data processing by the use of Excel software (instruction set correction oftemperature and pressure, averaging, coding). In final stage estimated of the safety and environmentalhealth condition of Andika city schools with used data processed. Results: Based on result, 77. 8% of urban and 80. 6% of rural schools had access to safe drinking water. In55. 6% of urban schools and 22. 6% of standard rural schools the number of abutments was observed. Theminimum required area per student is met in 100% of urban schools and 83. 9% of rural areas. According toresult this study, in 77. 8% of urban schools and 35. 5% of standard rural schools the number of toilets wasobserved. The standard of toilets was observed in 44. 4% of urban and 29% of rural schools. In 44. 4% of urbanschools and 35. 5% of rural schools, wastewater disposal methods were used according to health standards. Resul of study showed that 44. 4% of urban schools and 74. 2% of rural schools had health conditions. Conclusion: Findings showed that the safety and environmental health condition of schools has an effectiverole in efficiency and raising the level of education.

Background and Objectives: Dipeptidyl peptidase-4 inhibitors (DPP4-I) including sitagliptin is a new therapeuticclass of oral anti-hyperglycemic drugs for T2DM. The aim of this study was to evaluate the frequencyof glycemic control after adding sitagliptin on treatment regimen of patient with type 2 diabetic. Subjects and Methods: This cross-sectional study conducted on 120 patients with type 2 diabetes mellitusreferring to diabetes clinic of Imam Hospital, Ahvaz in 2019-2020. Sitagliptin (100 mg/day) was added tothe preexisting therapy for type 2 diabetes (metformin / metformin + gliclazide / metformin + insulin). Therapeutic effects and glycemic control (Changes in the glycated hemoglobin (HbA1c) level) after 3months of treatment were compared with the baseline. Results: The result of this study showed that after 3 months of treatment the level of FBS, BS-2h andHbA1C in 3 groups were significantly reduced compared with before treatment (P<0. 0001), but the patientsweight in the three groups were not significantly changed (P=0. 568). There was no significantdifference in the frequency of glycemic control between the patients treated with different concomitantdrugs (P=0. 501). The Results: revealed that patients younger age (P=0. 041), shorter disease duration(P=0. 021) and with higher HbA1c levels at baseline (P<0. 0001) were likely to show more decreased inHbA1c levels. Conclusion: Our study shows that sitagliptin (in combination with different type of treatment regimens)has the potential to improve glycemic control and prevent hypoglycemia and weight gain, and can beconsidered a useful drug in patients with type 2 diabetes mellitus.

Background and Objectives: Diabetic neuropathy is one of the most common complications of diabetesand no suitable drug treatment has been found for this complication. The aim of this study was to determinethe effect of six weeks of aerobic exercise on KIF1B protein in the sensory part of the spinal cord inrats with diabetic neuropathy. Subjects and Methods: In the present experimental study, 12 male Wistar rats were divided into 4 groups: healthy exercise, control exercise, healthy diabetes and control diabetes. The training program included6 weeks of running training on the treadmill in 5 sessions per week. The dorsal part of the spinal cordwas analyzed as sensory neurons. Results: The results showed that aerobic exercise significantly reduced blood glucose in the diabeticgroup compared to the control diabetes group (P=0. 002), but no significant difference was observed inthe weight of rats. The results also showed that a significant increase (P=0. 044) in KIF1B in healthy exercisegroup compared to healthy control group and a significant increase (P=0. 027) in KIF1B in diabeticexercise group compared to control diabetes. Conclusion: The results showed that aerobic exercise increases the amount of KIF1B protein in healthyand diabetic rats, and this increase in KIF1B motor protein can improve axonal transmission and thusimprove nerve function.

Background and Objectives: Type 1 diabetes is one of the most common chronic diseases in children. Theaim of this study was to determine the effect of eight weeks of regular exercise training and Ganodermasupplementation on glycemic control in children with type 1 diabetes. Subjects and Methods: In this quasi-experimental study, 40 boys with type 1 diabetes were selected anddivided into 4 groups: 1) exercise, 2) supplement, 3) exercise & supplement 4) control. Exercises included8 weeks, 3 sessions per week and each training session included selected exercises training. Ganodermalucidum consumption for daily consumption of 20 grams of a brewed drink was consumed. Fastingblood sampling was performed 48 hours before and 72 hours after the intervention. Results: A significant decrease was observed in 2Hour Post Prandial Glucose in the exercise & supplementgroup compared to the control group (P=0. 018). Also Significant decrease was observed in HbA1c level inexercise (P=0. 031) and exercise & supplement (P=0. 043) compared to the control group. Conclusion: According to the results, it can be said that combined exercise training can play an importantrole in the management of blood sugar in type 1 diabetes and the use of Ganoderma can increase theeffectiveness of exercise in blood glycemic control along with exercise training.

Background and Objectives: Cancer is the second leading cause of death in the world after cardiovasculardisease, so the aim of the present study was to investigate phthalimide and naphthalimide derivatives inorder to develop anticancer compounds. Subjects and Methods: In this study, the cytotoxic activity of six phthalimed and naphthalamide derivativeswas evaluated using MTT method on three cancerous cell lines, including breast cancer (MCF-7), ovarian cancer (SKOV3) and lung cancer (A549) cell line. Molecular Docking studies were also performedto determine the binding energy and the compounds interaction with DNA as a possible target of thesecompounds. Results: Based on MTT results, compound C1, a naphthalimide derivative, showed the highest cytotoxicactivity. IC50 values of this compound against MCF-7, SKOV3 and A549 cancer cell lines were 1. 7, 6. 2and 9. 5 μ, M, respectively. Also, comparison of phthalimide and naphthalimide derivatives showed thatcompounds C1, C3, C5 with carboxyl group had better effects than other compounds, C2, C6, C4, whichbearing 5-amidoisophthalic acid moiety. Conclusion: In general, naphthalimide derivatives showed better cytotoxicity than phthalimide derivatives. Compound C1 has the highest cytotoxic activity on all three cancer cell lines and can be furtherstudied in the development of new anti-cancer compounds.

Background and Objectives: Periodontitis is an inflammatory disease that involves supporting tooth structure, can be affected by risk factors like smoking, and increase the prevalence and severity of periodontal damages. Antioxidant stress to target molecule and prevent from degeneration of normal cells. This study aimedto compare the salivary total antioxidant level in smokers and non-smokers with chronic periodontitis. Subjects and Methods: A case-control study was performed in 60 chronic periodontitis patients (30 smokersand 30 non –,smokers) in referral patients to Ahvaz Jundishapoor university of Medical Sciences, School of Dentistry. Saliva samples were collected from all subjects and the total salivary antioxidantlevel in these subjects measured with the spectrophotometry method in 600 nm wavelength. data analyzedwith t-test statistical analysis. Results: A significant difference between total salivary antioxidant level in smokers and non-Smokers patientswith chronic periodontitis observed (P<0. 001). Conclusion: This study showed decreasing in total salivary antioxidant level in the smoker-patients withchronic periodontitis compared to non-smoker patients with chronic periodontitis.

Background and Objectives: Chronic Kidney Disease (CKD) is characterized by progressive and irreversibleloss of renal function. One of the complications of this disease is muscle wasting and atrophy. The aimof this study was to determine the effect of exercise training on CKD-induced muscle apoptosis in rats. Subjects and Methods: In the present developmental study, 30 rats were selected and divided into 3groups: disease training, disease control and healthy controls. Induction of CKD was through primaryand final 1. 3 resection of one kidney and complete resection of the other kidney. The training programconsisted of eight weeks of continuous running training with an intensity of 45-55% VO2max. After removalof EDL muscle, protein level and Bcl-2 and Bax gene expression were measured by immunohistochemistryand real-time PCR, respectively. Results: Induction of CKD caused a significant increase in protein level and gene expression of Bax andBax/Bcl-2 and a significant decrease in Bcl-2 compared to the healthy control group (P<0. 001). Also significantdecrease was funded in the expression of genes and proteins Bax and Bax/Bcl-2 (P<0. 001) anda significant increase was funded in protein Bcl-2 (P<0. 001), without significant changes in the geneexpression of Bcl-2 (P=0. 935) in disease training compared to the disease control. Conclusion: The results of the present study support the anti-apoptotic effect of exercise on muscle tissueof CKD patients,therefore, it is recommended that clinical research be conducted in this regard forexercise recommendations for these patients.

Background and Objectives: One of the ways to deal with Covid-19 disease is 19 preventive behaviorsthat seem to be affected by different factors. Therefore, the aim of the present study was to predict thepreventive behaviors of Covid-19 disease based on health literacy with the mediating role of mediainformation belief and social responsibility. Subjects and Methods: This descriptive and correlational study was performed on 247 adults in Ahvaz inthe summer of 2020. The research sample was selected using available sampling and they answeredonline the questionnaires whose validity and reliability were confirmed. . Data were analyzed using Spss, Amose software, descriptive and analytical statistics. Results: The results showed that the indirect coefficients between believing in media information (P=0. 000, β, =0. 04) and social responsibility (P=0. 000, β, =0. 11) with preventive behaviors of corona disease were significant. The proposed research model also had a good fit (RMSEA= 0. 05, P=0. 20, X2/df: 1. 63, X2: 1. 63). Conclusion: The results showed that health literacy is both directly and indirectly related to corona diseaseprevention behaviors through belief in media information and social responsibility. Therefore, toincrease the preventive behaviors of corona disease in individuals, we can use the influence of the mediaand strengthen social responsibility in individuals.