In this study, the effective factors on Total Factor Productivity (TFP) with the emphasis on human capital indices, technology and management, have been studied. The goal of this research apart from the calculation of total factor productivity in the period of 1374-1388, is the analysis of effective factors on total factor productivity, reasons of productivity differences in chemcal industry. For this reason, Divisia method for TFP calculation and Panel Data technique for the effectiveness of impressive factors on productivity, has been used. The effective factors on Total Factor Productivity in estimated pattern are as below: The percentage of the high-educated employed people (official education), per capita cost for educational enterprise (unofficial education), research and development stock and utilization rate of the capacity. The studying results show significant and positive effect of the below factors: The percentage of the high-educated employed people, per capita cost for educational enterprise, research and development stock, value output and utilization rate of the capacity to Total Factor Productivity and the negative effect pupulicat to enterprise value output.Among mentioned factors, the percentage of the high-educated employed people, enterprise scale of production and utilization rate of the capacity have the most significant effect on total productivity progress.