Introduction: Health and health organizations face many challenges including the multiplicity of professors, students and employees, the broad range, interaction with the general public, modern changes in the world health system, and the importance of updating information. To overcome these challenges and improve the quality of health services, it requires organizational entrepreneurship, use of skilled staff and proper time allocation for knowledge management. Methods: This research is a practical and descriptive and is considered as a qualitative research group. The research community has 20 people who have been expert in the GHazvin University of Medical Sciences for over five years. MAXQDA 10 has been used to analyze the results of deep interview. Results: 18 Fundamental categories were used to explain the model of organizational entrepreneurship development based on knowledge management of GHazvin University of medical science. Conclusion: Contextual conditions: (individual skills and characteristics, cultural and social conditions, organizational structure, political and legal conditions), Causal conditions: (knowledge management [acquisition and create, save and retention, share, reuse), Intervening conditions: (organizational culture and human resources), Central category (model of organizational entrepreneurship development based on knowledge management of GHazvin university of medical science. ), Outcomes: ( behavioral, structural and content ) and its Strategy is organizational development.