Abortion and fetal loss are the most important problems in industrial dairy cattle, which causing a lot of economic losses to dairy herds. Abortion causes are classified into two major classes. Infectious and non-infectious classes, Bacterial, viral, fungal and protozoal agents are in infectious causes of abortion and nutritional factors, chemicals, drugs, poisons, are in non-infectious class, poisonous plants and hormonal factors are in non-infectious causes of abortion. Many infectious agents cause changes in fetus and placenta which some of them are specific and some are shared with other agents. Many aborted fetuses can be detected by careful review of pathological findings and can be solved in order to be tried in the herd. Pathological changes in aborted fetuses can be investigated by macroscopic and microscopic survey. On the basis of existing studies, some of the pathological lesions are completely specific and can be detected by microscopic observation. To determine the causes of abortion in Tehran province dairy herds and their macroscopic and microscopic lesions, 200 aborted fetuses were collected in four consecutive seasons. After necropsy, the macroscopic lesions in their various organs were observed and tissue samples obtained from the brain, cerebellum, heart, liver, spleen, kidney, lung and skeletal muscle were fixed in neutral buffered 10% formalin, routinely embedded in paraffin and stained with H&E. The results of this study showed that most abortions in dairy herds of the west region of Tehran province are due to 4 diseases: Neosporosis, BVD, Leptospirosis and IBR. On the basis of these results, each one had its specific histopathological characteristics which can be used for the purpose of diagnosis.