Technology, as a major driver in the fields of science and innovation, has many consequences in various areas of development in the country. The increasing speed and acceleration of production, evolution and transfer of technology has doubled the importance of recognizing the developments and changes in this field. And the lack of knowledge and theory in the field of the nature of technology, its functions and consequences has laid the groundwork for the phenomenon of managerial and policy lag in this area. The purpose of this study is to identify the epistemological challenges of technology governance and provide solutions for the Islamic Republic of Iran. Accordingly, the research question is, based on the research conducted, what are the epistemological challenges in technology governance and what solutions can be offered for the Islamic Republic of Iran. The research method is documentary analysis and thematic analysis and the research conducted in the field of science, technology and society studies in the last ten years has been used. Among the most fundamental problems in technology governance are the epistemological ambiguity in the nature and philosophy of technology, technology and political domination, technology and the decline of real communities, technological determinism, the dominance of technology over culture (technology), technology and the power of change, technology and expansion. Inequality, technology and normalization, technology and changing patterns of economic development, technology and shaping the center-periphery world, technology and alienation, technology and changing patterns of consumption, technology and moral consequences, technology and changing lifestyles. In the summary section, philosophical and epistemological challenges, socio-cultural challenges, political challenges and economic challenges are separated and categorized.