Soil unsaturated zone is one of the important parts of hydrological cycle that has an especial role in agricultural water resources management. The objective of this research was to determine the amount of root water uptake under simultaneous water, salinity, and nitrogen stresses as prevailing conditions in arid and semi-arid regions. To do so, the experiment was conducted with four quantitative levels of irrigation water including 120, 100, 80, and 60 percent of crop water requirement, four qualitative levels of irrigation water including 1.2, 3, 5, and 8 dSm-1 and four nitrogen fertilizer levels including 100, 75, 50, and zero percent of fertility requirement. The results indicated that based on calculated statistics, the basil response was suitable simulated by MB-MB-EXP model under simultaneous triple water, salinity, and nitrogen stresses (nRMSE=7.22 and ME=19.05). The sensitivity analysis of the models indicated that MB-MB-VG model with the lowest input parameters and relatively low sensitivity to these parameters (Sc<1.5) has a better accuracy than other studied models (nRMSE=7.45 and ME=19.75).