Background and Objective: General health, resilience, emotional intelligence, marital conflict, parenting exhaustion, attachment and parent-child interaction contribute to the psychological empowerment of mothers. The aim of this study was to determine the structural relationships between general health, resilience, emotional intelligence, marital conflict, parenting burnout, attachment, and parent-child interaction with psychological empowerment among mothers with children aged 4-6 year-old. Materials and Methods: This descriptive-correlational structural equation study was conducted with the participation of 257 mothers with children aged 4 to 6 years in the winter of 2019 in Isfahan city. Available sampling method was used. Data were collected using questionnaires of general health, resilience, psychological empowerment, emotional intelligence, marital satisfaction, parenting burnout, relationships between attachment and parent-child interaction. In order to model structural equations, SPSS Statistics for Windows, version 23. 0 (SPSS Inc., Chicago, Ill., USA). and PLS3 software were used. Results: Direct coefficients of variables of emotional inte ige ce β, =0 41, t=6 9, resi ie ce β, =0 24, t=3 9, d rit s tisf cti β, =0 15, t=2 4 with psychological empowerment were significant but, direct correlation c efficie ts betwee tt ch e t β, =0 03, t=0 39, p re ti g bur ut β, =0 08, t=1 2, ge er he th β, =-0. 02, t=0. 24), parent-chi d i ter cti with ps ch gic e p wer e t β, =0 05, t=0 62 w s t sig ific t I direct c efficie ts f relationships between attachment through parent-chi d i ter cti d resi ie ce β, =-0. 04, t=2. 7), general health and resi ie ce β, =-0 03, t=2 5, ge er he th d rit s tisf cti β,=-0. 02, t = 2. 2), parent-child interaction and e ti i te ige ce β, =-0. 08, t=3. 6), parent-chi d i ter cti d rit s tisf cti β, =-0. 02, t=2. 01), general health, d e ti i te ige ce β, =-0. 04, t=2. 5) with psychological empowerment were significant. Also, the indirect coefficients of relationships between parenting burnout through parent-chi d i ter cti d resi ie ce β, =-0. 01, t=1. 99), general health and resi ie ce β, =-0. 05, t=3. 1, ge er he th d rit s tisf cti β, =-0. 04, t=2. 3), parentchi d i ter cti d e ti i te ige ce β, =-0. 02, t=2. 603), and general health and intelligence emotion on ps ch gic e p wer e t β, =0 07, t=3 52 were significant. Conclusion: The study showed that emotional intelligence, resilience and marital satisfaction are among the variables that have a direct effect on psychological empowerment, and the relationship between attachment and parenting exhaustion is one of the variables that have an indirect effect on psychological empowerment.