Complex product systems (COPS) play an important role in industry, economics and technology of countries. On the other hand, Due to the complexity and the need for in depth and high level knowledge; organizations face challenges in Manufacturing and developing these products. To succeed in manufacturing of these products, organizations need to recognize the required capabilities. Therefore, the current research was conducted to identify the capabilities and enablers needed to manufacturing complex products And analyzes the causal relationships between these enablers. The other purpose of this study was to determine the importance of these factors for the accurate planning in the organization. For this purpose, with using the library studies and semi-structured interviews, the mentioned capabilities were identified and then validated by distributing the questionnaire. Eventually, 10 main factors and 46 sub-factors were identified. In the next step, with using Interpretative Structural Modeling (ISM) method, the relationships between these factors were determined and partitioned into four levels. Then ANP was used to determine the weights and ranking of factors. The research results show that networking capabilities, projects management, system integration and interactions at macro levels are the most important factors in manufacturing complex products and have underlying impacts on other factors. at the end of paper, after concluding the content, some suggestions were proposed for future research.