Introduction and objectives: Stuttering has multiple biological, cerebral, and psychological dimensions, all of which are necessary for better understanding of the disorder. The aim of this study was to investigate depression among people with and without stuttering. Materials and Methods: The present study was a systematic review. In order to obtain related studies, studies conducted until before 15th of Ordibehesht in 1400 (May 6, 2021) were skimmed using such key terms as: depression, mental disorder, mood disorders, speech disorder, and stuttering through international databases such as WEB OF SCIENCE, SCIENCEDIRECT, SCOPUS, SPRINGER, GOOGLESCHOLAR, and internal databases such as SID, NOORMAGS, MAGIRAN, and ISC. Finally, 321 study were skimmed and 10 study were selected to meet the objectives of this study. Results: The results showed that depression in children and adolescents with stuttering is more than children and adolescents without stuttering. Likewise, the rate of depression increases with age, which is more severe in girls with stuttering. The results for depression in adults with stuttering are somewhat contradictory, though most studies have shown an increase in stuttering in adults with stuttering compared to adults without stuttering. Conclusion: It seems that depression is more common in people with stuttering than without stuttering. Therefore, in addition to solving speech problems of these people, paying more attention to mental disorder such as depression is suggested.