Introduction: The Covid-19 pandemic is an unprecedented scenario for all countries. In this disease, the importance and role of nurses is very important because of long-term contact with patients. In the corona epidemic, nurses are exposed to job burnout, which means physical, emotional and mental fatigue due to being in a difficult work position for a long time. This article aims to determine the effective factors of nurses' burnout in the era of covid-19, the strategies to deal with it and the obstacles in carrying out interventions. Methods: The current study is a descriptive review that was conducted through an online search in the scientific databases PubMed, Direct Science, Web of Science and ISI in the period from 2019 to 2022 using the keywords Burnout, Nurses, Epidemic and Covid-19 in English. And obtained by using Boolean operators. Also, the search was conducted in Google Scholar search engine in English. The inclusion criteria included studies that dealt with the factors related to job burnout and its solutions. Exclusion criteria included lack of access to the full article. A data extraction table was used to analyze and categorize the data. Results: The present study is a descriptive review type that was conducted through online search in scientific databases PubMed, Direct Science, Web of Science and ISI in the period from 2019 to 2022 using the keywords Burnout, Nurses, Epidemic and Covid-19 in English and obtained using Boolean operators. The inclusion included studies that addressed the factors related to job burnout and its solutions and were available in the Google Scholar search engine. An extraction analysis table was used for the direction and classification of data. Conclusions: According to studies, job burnout is more in female nurses and has a direct relationship with variables such as stress, workload, lack of personal protective equipment, environmental problems of hospitals and concern about the risk of disease transmission. Careful planning and preparation of governments and health systems, training, providing appropriate psychological programs, Telehealth, resilience programs, family support and participation of nurses when adopting policies are appropriate solutions to face burnout of nurses. Things like the label of the disease carrier, fear, uncertainty are obstacles to doing interventions.