Background and aims: Premenstrual syndrome is a set of physical and emotional psychological symptoms which occur periodically during the secretory phase of the menstrual period and this study was aimed to determine the effect of Vitagnus on physical/emotional symptoms of PMS.Methods: This clinical double-blind study was conducted on 72 girls suffered from premenstrual syndrome at a dormitory of Shahid Chamran. The samples were then randomly divided in two 36-member groups, case and control. Case group was prescribed with 40 drops of Vitagnus daily for three menstrual cycles, while the control group was given placebo. Data collection tools were collected using questionnaires, menstrual daily records and grading symptoms and physical/emotional symptoms of participants before and after intervention were registered and compared.Results: The findings of this study revealed that a significant improvement in physical symptoms including breast pain and tenderness, acne, flatulence, headache, hand and foot swelling, muscle and joint pain was observed based on score mean before and after intervention in case group (P<0.05). Moreover, the mean score of motional symptoms in premenstrual syndrome (sleep disorder, difficulty in thinking and remembering, loneliness, feeling of being unattractive, hopelessness, craving for sweet or salty food, restlessness and feeling nervous) was showed a significant difference between two groups, case and control, before and after intervention (P<0.05).Conclusion: Findings revealed that taking Vitagnus before a menstrual cycle can relieve emotional and physical symptoms of PMS. So, regarding the little side complications, consumption of Vitagnus has a useful effect on premenstrual syndrome.