Background and aims: Non-adherence to treatment is a common problem among hemodialysis patients and was considered as a responsible factor in patients deteriorating, increasing admission chance and inappropriate responding to hemodialysis treatment. Regarding to multiple factors related to non-adherence to hemodialysis treatment and its importance in patients' quality of life, this study aimed to determine the treatment adherence condition among hemodialysis patients referred to Hajar Hospital, Shahrekord, Iran.Methods: In this descriptive analytic study, 71 hemodialysis eligible patients among 118 hemodialysis patients who referred to Hajar Hospital in Shahrekord, were selected according to goals center sampling method. The data were gathered by demographic, laboratory and end-stage renal disease adherence questionnaire (ESRD-AQ).Results: The mean score of adherence to hemodialysis treatment was 858.60 ± 192.45. Majority of patients had moderate adherence to hemodialysis treatment in four adherence dimension: medication (56.3%), diet (78.9%), fluid restriction (70.4%), and hemodialysis schedule (78.9%). Intradialytic weight gain was abnormal in 88.7% of patients. Furthermore, age and gender of patients had significant relationship with treatment adherence (P<0.05).Conclusion: Regarding to finding of this study, treatment adherence condition in hemodialysis patients referred to Hajar Hospital in Shahrekord is moderate and probably related to chronic nature, economic problem and their knowledge deficit of them. Therefore, paying more attention to causes of non-adherence to treatment in hemodialysis patients is necessary.