Introduction: E-learning is one of the most important and common paradigms of ICT in educational areas. It may help promote creativity, an important, basic and effective component of human life. The aim of this paper is to study the effect of e-learning on students' creativity at Meshkinshahr Payame Noor University in the 2012-2013 academic year.Materials and Methods: A quasi experimental design with a control group was used in this study. All students of Payame Noor University of Meshkin Shahr (2500) were the population that was studying in 2013-2014 academic year. The sample, which was selected through the access sampling, consisted of the students having two pre-pre-elementary courses (60 students). Abedi creative questionnaire was used as the research tool. The validity was assessed through the internal consistency method which showed 0.79 for the creativity questionnaire. The reliability was assessed via the retest method which showed 0.85 for fluid, 0.82 for invention, 0.84 for flexibility, and 0.80 for expansion. For statistical calculation, SPSS software, version 16 was used. T-test was used to examine the hypotheses.Results: The results showed that e-learning had a significant effect on students' creativity (p<0.5).Conclusion: Based on the results, e-learning can be considered as an effective factor promoting the students' creativity. Therefore, material planners and instructors should pay due attention to it.