Background and Aim: Work-related musculoskeletal disorders are the most important occupational diseases. This study aimed to investigate the correlation between company ergonomic situation and anthropometric dimensions with musculoskeletal disorders in workers. Methods: 82 female and male volunteer workers participated in this cross-sectional study. The musculoskeletal disorders, ergonomic situation, and anthropometric dimensions were examined using the Nordic and Dutch musculoskeletal questionnaires and tape meters. The study protocol was approved by the Committee for Ethics in Biomedical Research of the Allameh Tabataba'i University with obtaining ethics. Data were analyzed using SPSS ver. 26 software and running Spearman and Chi-Square tests at the significance level of 0. 05. Results: Significant correlations were found between the company ergonomic situation with musculoskeletal disorders in the neck (P=0. 001), shoulder (P<0. 001), elbow (P=0. 004), wrist (P=0. 004), upper back (P<0. 001), lumbar (P<0. 001), thigh and buttock (P=0. 028), knee (P<0. 001), and ankle (P=0. 036). Moreover, there were significant correlations between the ratio of chair height to popliteal height with musculoskeletal disorders in lumbar (P=0. 026), thigh and buttock (P=0. 015), knee (P<0. 001), and ankle (P=0. 038), also between the ratio of chair depth to thigh length with shoulder (P=0. 043), upper back (P<0. 001), lumbar (P<0. 001), thigh and buttock (P=0. 001), and knee (P=0. 004), and between the ratio of chair height to shoulder height with shoulder region (P=0. 002). Conclusion: It seems that there is a correlation between company ergonomic situation and the proportion of anthropometric dimensions with chair dimensions with the prevalence of musculoskeletal disorders in workers.