Introduction: As a consequence of using fossil fuels, some hazards such as explosion and fire are probable. This study was aimed towards consequence modeling of fire on methane storage tanks in a gas refinery using risk analysis, as well as modeling and evaluating the related consequences.Methods: Hazard analysis by PHA was used to choose the worst case scenario. Then, causes of the scenario were determined by FTA. After that, consequence modeling by the PHAST software was applied for consequence analysis.Results: Based on some criteria, the fire of methane gas tank (V-100) was selected as the worst case scenario at the refinery. The qualitative fault tree showed three factors including mechanical, process, and human failure contributing in gas leakage. The leakage size and weather conditions were effective on the distance of radiation. Using consequence modeling, thermal radiation was considered as the major outcome of the incident. Finally, for outcome evaluation, probit equations were used to quantify losses and the percentage of fatalities due to methane gas leakage and fire occurrence. The maximum number of fatalities caused by fire was obtained as 23 persons.Conclusions: In conclusion, the methane gas vessel in a refinery can be considered as the main center of hazard; therefore, the implementation of safety rules, eliminating mechanical failures, personal protection and education, and effective measures to prevent and fight fire are proposed for decreasing the probable losses and fatalities.