ALBORZ UNIVERSITY MEDICAL JOURNAL
Year:2016 | Volume:5 | Issue:4|Papers Count:8

Background: Prostate cancer is the second most common cancer in America which causing great harm and waste cost. Furthermore almost more prostate cancer treatments are ineffective. Purpose of this study was to evaluate the effects of therapy and the rate of increase of the absorbed dose of gamma radiation with silver nano particles in treatment of prostate cancer.Materials and Methods: DU145 cell line originating from Human prostate cancer was purchased from Pasteur Institute. After thawing of defreezed samples, cells were incubated with DMEM medium and 15% FBS Confluency FBS serum was added. For preventing contamination amphotericin B in 25 mM/ml was added. Cells were incubated over a period of 3 to 5 days to reach a good Confluency Then cells divided into 4 groups. Tentatively assigned to the control group, the second experimental group treated with gamma irradiation at a doses of 2, 6 and 10 Gy, the third group treated with 53mg/ml م g/mlµ 53 silver nano particles. The fourth group includes simultaneous treatment with gamma doses and silver nano particle.انکوبه و  Cell groups studied by staining with trypan blue as well as by MTT assay (ELISA) reader.Results: The results showed the use of gamma rays and silver nano particles caused a significant reduction in the number of cancer cells in the treated groups compared to the other treatment groups and a control group. Using of silver nano particles as a radio sensitizer and radiation therapy in prostate cancer cell lines DU145 resulted in the increase of the gamma-ray photon energies of 6 and 10 Gy.Discussion: The gamma photon radiation to the tumor cells were incubated nano particle probability Photoelectric process as a process when handling the extremely high energy gamma photons hitting the silver nano particles to cancer cells, photoelectron and Auger electrons (Auger Electrons) and secondary electrons produced by secondary particles can be. It will not be very effective, leading to failures in the field of DNA damage and cell death.

Background: Bloating, is a common complication in patients with stroke; that increased intracranial pressure due to cerebral hypoxia in these patients. Most drugs have adverse effects to relieve flatulence. So this study aimed to investigate the effect of synbiotic supplement on stroke patients; was performed.Methods: The study, on 65 stroke patients; was done. They were randomly divided into two groups: control (n=32) and intervention (n=33) and the size of their abdominal circumference were measured before the study. The intervention group, in addition to routine treatment, for a week, every 12 hours, recived fermented prbiotic supplement Zhari Takhmir and the control group was given only a laxative (MOM=15cc) prescribed by a doctor. In the end, abdominal circumference in all patients were evaluated again. Data using analysis of covariance model, were analyzed.Results: After a week, abdominal circumference measurements in two groups showed that; in the intervention group on average waist size of 6.1 inches had reduced compared to baseline (p=0.028). But the changes were not significant in the control group.Conclusion: The study showed that a probiotic supplementation reduces abdominal circumference and distention in patients with stroke; Therefore, probiotics can be used as a non-drug therapy in the treatment of these patients.

Introduction: Psoriasis is a common inflammatory skin disorder with humeral and cellular immune system involvement. On the other hands, Vitamin D has important immunomodulatory effects and its relations with many autoimmune diseases were shown. The relation between Serum Vit D Level and Psoriasis disease remained controversial issue that this study was done to show this relationship.Methods and Materials: In this comparative cross sectional study, 30 psoriatic patients who attended to Razi dermatology clinic in Rasht, by sequential sampling underwent study as case group. 30 healthy people from hospital at the same age, gender and skin-colored also were selected as control group. Inclusion criteria were patients and people without Ca or Vit D supplements usage or underground diseases in relation to hypovitaminosis D. Demographical data were gathered by interviewing and then blood samples from all participants were sent for analysis of serum Ca, P, Vit D and parathormone level. Data analysis was done by SPSS ver. 18 using T-test and Chi 2 test.Result: Mean and SD serum level of Vit D in case and control groups were 25.8±12.6 ng/ mL and 23.7±8.9 ng/ mL, respectively (ρ>0.05). Out of all, 24 participants (40%) suffered from Vit D Deficiency and 20 people (33.3%) from Vit D insufficiency, only 26.7% study subjects had acceptable serum Vit D level. There were not any significant difference between Vit D deficiency rates and other measured biochemical indices in two groups (36.7% vs. 43.3%).Conclusion: This study showed high level of Vit D deficiency in both psoriatic and normal people that must be notice.

Background: Atherosclerosis is the main reason of Coronary Artery Disease (CAD). The studies show that several factors are interconnected with the development and progression of CAD including lipid peroxidation, inflammation and homeostasis. The aim of this study was to evaluate the serum level of Oxidized LDL (OX-LDL) and Malondialdehyde (MDA) and their association with the extent of Coronary Artery Disease.Methods: In this cross-sectional study serum OX-LDL and MDA levels were determined in 160 patients with Coronary Artery Disease comprised of 40 subjects with no vessel disease, 40 subjects with single vessel disease, 40 subjects with double vessel disease, and 40 subjects with triple vessel disease matched control healthy 20 subjects. Serum levels of OX-LDL determined used to (ELISA) procedure. Serum level of MDA was measured by photometric method based on reaction with Thiobarbituric Acid (TBA). Data were analyzed using Spearman correlation coefficients, Student's t test or ANOVA.Result: Oxidized LDL and Malondialdehyde serum levels in patient groups were significantly higher than control groups (p<0.05). Furthermore, serum concentrations of OX-LDL in double-vessel disease were significantly higher as compare with control and no-vessel groups and triple vessel disease were significantly higher as compare with single vessel disease (p<0.05). Serum concentrations of MDA in double-vessel disease were significantly higher as compare with control and no-vessel groups and triple vessel disease were significantly higher as compare with single vessel disease (p<0.05).Conclusion: Elevated serum levels of OX-LDL and MDA indicate potential role in atherogenesis leading to CAD. There for our findings suggest that determination of serum OX-LDL and MDA levels can be useful as diagnostic and monitoring markers in patients with CAD and its extent.

Background: Treatment of hydatidosis in humans, mainly surgery with the use of drugs is combined. During surgery, the risk of fluid leakage hydatid cyst that was content to adjacent tissues, resulting in recurrence of the disease. Ephedra is a plant that grows in various regions of Iran and used to treat as antibacterial and antifungal in certain diseases. The aim of this study was to in vitro evaluate the effects of different concentrations of aqueous extract of Ephedra major at different times.Materials and Methods: Infected liver to hydatid cysts were collected from slaughterhouses. Protoscoleces viability was assessed by staining Eosin 1.0 percent. Protoscoleces activities of aqueous extract 0.1, 0.01, 0.001 mg/ml at 10, 20, 30 and 60 minutes were analyzed. Saline and saturated brine were used as positive and negative controls.Results: The highest percentage of household protoscoleces dilution of 0.1 (13.58%) was observed (P=0.001). Protoscoleces lowest scolicidal effect rate was found in the dilution 0.001 (2.47%).Conclusions: The effect of aqueous extract of Ephedra major plumbing protoscoleces not significant. Therefore, it cannot be used as a cache protoscoleces strong and appropriate.

Background: Thioacetamide is a liver toxin that causes centrilobular necrosis. In this study, the protective effect of aqueous extract of Glycyrrhiza glabra root against liver-related biochemical factors changes induced by thioacetamide in male rats was investigated.Materials and Methods: 35 male rats were divided into 5 groups of 7: control group; sham group: receiving a single dose of 150mg/kg thioacetamide intraperitoneally; experimental groups 1 and 2 and 3: they received the aqueous extract of Glycyrrhiza glabra root at the doses of 100, 200, 300mg/kg daily orally during 3 months respectively and then a single dose of thioacetamide at 150 mg/kg as intraperitoneal injection. The serum levels of albumin, bilirubin and total protein were measured.Results: The mean of body weight in all experimental groups receiving aqueous extract of Glycyrrhiza glabra root and thioacetamide did not show significant changes compared to the group receiving thioacetamide. The mean levels of serum bilirubin in all experimental groups receiving aqueous extract of Glycyrrhiza glabra root and thioacetamide did not show significant changes compared to the group receiving thioacetamide. The mean of serum albumin concentration in all experimental groups receiving aqueous extract of Glycyrrhiza glabra root and thioacetamide decreased significantly compared to the group receiving thioacetamide. The mean of serum total protein concentration in experimental groups receiving aqueous extract of Glycyrrhiza glabra root and thioacetamide did not show significant changes compared to the group receiving thioacetamide (p<0.05(.Conclusion: The results of this study showed that the aqueous extract of Glycyrrhiza glabra root had protective effects against liver-related biochemical factors changes induced by thioacetamide in male rats.

Background and Purpose: Social media has important role in educational programs. This study aimed to psychometric of the attitudes towards social media learning scale.Methods: This psychometric study included 119 participants from medical schools around Iran. The initial instrument was adopted from previous studies and had eight questions based on the Likert scale. The instrument verification procedure included examining the impact factor, the content validity index (CVI) and the content validity ratio (CVR) based on the judgment of 10 experts. Its internal validity was examined by an exploratory factor analysis. The internal reliability of the scale was determined by the Cronbach’s Alpha coefficient and the external consistency was assessed by using the test-retest method.Results: In the initial scale, all of the 8 items were kept with an impact item index of over 1/5, the CVR over 0.62, and CVI of over 0.7. Based on exploratory factor analysis, all of the 8 items were maintained in the scale. Considering a minimum eigenvalue of 1 for each factor, the following three factors: communications in learning, reflective learning, and interactive learning were extracted. This instrument was capable of predicting 69.416% of the changes of the whole scaleConclusion: The results of this study indicated the strength of the factor structure and reliability of the instrument for measuring attitudes toward learning via social media. The results of study can assess students’ attitudes in this regard in universities and other educational institutes.

Backgrounds and Objective: Physical activity is one of the important and effective factors associated with the human health. The elderly are among the most vulnerable groups in many diseases and disorders that exercise can prevent of many of these diseases. The aims of this study is to determine the level of physical activity among elderly of Karaj city and its relationship with some the demographic factors.Materials and Method: This cross-sectional study was conducted in the first half of 2014 and in health centers of Karaj city, Iran. The study population were people older than 60 years (n=286) who referred to these centers. A short physical activity questionnaire (IPAQ) was used to collect data. Data were analyzed by SPSS and the descriptive and analytical tests.Results: The age mean of elderly was 67.37±6.5 years. The majority of them (52.4%) were woman & (54.2 %) were in families with 4-6 members. About physical activity level in participant finding show that 50.5% were in low level, 43.1% intermediate and 6/4% were in high level. A significant relationship was between gender & job in elderly with level of physical activity (P<0.05).Conclusion: According to the results it seems that for encourage and remove the barriers of doing physical activity in elderly, basic plans must be done at the macro level of management. So it is suggested that more researches and interventions about barriers of doing physical activity be done in elderly of Karaj city.