Introduction: Diabetes is the most common metabolic disease. Studies have shown that early detection and proper treatment of acute and chronic complications of Diabetes can be prevented. We conducted this epidemiologic study to determine the risk factors in patients with type 2 diabetes in Kashmar, to prevent the disease and its complications.Methodology: This cross-sectional study, were carried on 400 patients with type 2 diabetes (200 women and 200 men) who referred to internal clinic of Moddares Hospital in Kashmar respectively. Questionnaire was used and other data were collected. Height and weight measured using with standard methods and BP was measured twice using a standard mercury sphygmomanometer in the sitting position. Data analysis was performed by SPSS software.Results: The means of age, weight and blood pressure of subjects, were 57.19, 79.51 and 134.71 respectively. We found significant relation between complications, and factors such as smoking, (p=0.005), physical activity, (p=0.000), hypertension, (p=0.000), obesity, (p=0.009), and aspirin taking (p=0.000).Conclusion: The results showed, there are many amendable risk factors in patients with type 2 diabetes. It appears that preventing of disease and its complications, is based on the training of healthcare workers, patients, their families and finally community. Also individuals are at risk for diabetes should be screened to live more and have a healthy and better life.