To evaluate the effects of organic and chemical fertilizers on the leaf area index, yield and yield components of pumpkin, a field experiment was conducted based on RCBD with three replications during the 20 10-2011 growing season at Gorgan University of Agricultural Sciences and Natural Resources, Iran. The treatments included N: (control), N1: 66 66-99 kg ha-1 NPK, N2: 132-132-198 kg ha-1 NPK, N3: 300-200-200 kg ha-1 NPK, H: 30 t ha-1 manure, HN1: (1.2 H + N1), HN2: (N2 +1.2 H), HN3: (N3 +1.2 H), C: 30 t ha-1 municipal compost, CN1:(1.2 C + N1), CN2: (1.2 C + N2), CN3: (1.2 C + N3) and HN: (1.2 C + 1.2 H). In this study, total dry weight, leaf area index, number of fruits per plant, number of seeds per plant, 1000-seed weight and seed yield were measured, The results showed that the application of chemical fertilizer (N3: 300-200-200 kg ha-1 NPK) decreased seed yield, The effect of manure and solid waste compost application was positive on both physiological indices and seed yield, Application of Chemical and combined fertilizers (N2: 132-132-198 kg ha-1 NPK and HN2: (N2: 132-132-198 kg ha-1 NPK + 15 t ha-1 manure) had a positive effect on all traits. The use of chemical fertilizer with FYM (HN2: (132-132-198 kg ha-1 NPK + 15 t ha-1 manure) produced the highest value of physiological indices and seed yield. In total, the results showed that the application of an NH2 treatment -instead of chemical fertilizers, in addition to the considerable reduction of chemical inputs, can be a step towards achieving sustainable agriculture.