Pot marigold (Calendula officinalis L.) belongs to Asteraceae family is a medicinal herb which its flowers have diverse pharmaceutical, cosmetic and nutritional uses. In order to study the effect of organic fertilizers on agronomic performance, yield and quality characteristics of pot marigold, a field experiment was conducted based on randomized complete block design with three replications in Research Station of Faculty of Agriculture, College of Agriculture and Natural Resources, University of Tehran, Karaj, in 2010. Treatments were vermicompost (15 t ha-1, municipal waste compost (20 t ha-1), cattle manure (25 t ha-1, mushroom compost (15 t ha-1 and control (without fertilizer). Quantitative and qualitative criteria such as plant height, number of branch per plant, number of flower per unit area, flower diameter, herbal fresh and dry weight, 1000 seed weight, flower and seed yield and content of essential oil and extract were measured. Results revealed that among different organic inputs, vermicompost performed better and significantly increased plant height, number of branch per plant, number of flower per unit area, 1000 seed weight, herbal fresh and dry weight and flower and seed yield. Whereas there were no significant difference between cattle manure and municipal waste compost in plant height and also with vermicompost in 1000 seed weight Application of cattle manure resulted in highest flower diameter and extract content Although, there were no significant difference between cattle manure and vermicompost in flower diameter and extract content improvement. Yield and all plant criteria were decreased with mushroom compost application. In general, this study indicated that vermicompost could be an alternative organic input instead of chemical fertilizers in sustainable production system of C. ojjicinalis.