Due to the integrity and divinity of the Islamic jurisprudence it plays a unique role in human life. However, there isn’t a practical and comprehensive model for the application of Islamic law in the political and social system. The importance of this matter moved the author of this paper to study the process of achieving jurisprudence doctrine of Imam Khomeini (RA). First, the jurisprudence system is analyzed with regard to the recognition at law and with emphasis on Imam Khomeini (RA) thoughts. Then three layers of jurisprudence, philosophy and mysticism, ethics and common law, are introduced and entitled: major jurisprudence, mediocre jurisprudence and minor jurisprudence. In fact, the system of jurisprudence, characterize theoretical framework. Later, the analytical framework of the doctrine, is explained as a good model to express the results of the first part in the form of instructions for governance. In this qualitative study, has been accomplished using documents and library resources.