The following article is orchestrated on the basis of scenario-based processing as one of the main methods of future study. It tries to answer this main question that “what would be the probable direction of the Salafi jihadist groups such as Al-Nusra Front and Islamic state of Iraq and Syria (ISSI) in the Middle East? It seems that five scenarios can be anticipated in three categories: A) Favorable scenario: 1) the final destruction of Takfirijihadi Islamists and democratically distribution of power under the ceremonial leadership of Bashar al-Assad 2) suppression of takfiri groups and ruling of the Islamic Republic, instead of the Arabic Republic of Syria and Iraq. B) Probable scenario: 1) the elimination of Da’ash and distribution of power between Kurds, Shiites and Sunnite in Syria 2) Breakup of Iraq and Iraqi Kurdistan's independence. C) Possible scenarios: 1) capturing Baghdad and Beirut government and establishing the government known as the Islamic regime by takfiri-jihadi groups. In order to keep their own entities, the political systems of Syria and Iraq should carry out reforms mainly in the political, economic and social realms.