2Introduction: Spinal cord injury is a debilitating condition that has numerous physical, psychological, and social impacts. This study aimed to assess the impact of quality-of-life therapy on life satisfaction, positive emotions, and aggression among spinal cord injury patients in Isfahan. Methods: The research employed a semi-experimental approach with a pre and post-test design and a control group. The study's statistical population comprised all patients with spinal cord injuries who were referred to the welfare and rehabilitation centers of Isfahan in 2017. To conduct the study, thirty individuals with spinal cord injuries who met the entry criteria and expressed willingness to participate were selected using convenience sampling. They were then randomly assigned to either the experimental or control group, with fifteen individuals in each. Both groups completed research instruments, including the Life Satisfaction Questionnaire (Diener, 1985), Positive Affect (Watson et al, 1988), and Aggression (Buss & Perry, 1992), before and after the intervention, as well as one month after follow-up. The experimental group received quality-of-life therapy (Frisch, 2006) in eight ninety-minute sessions, while the control group did not receive any intervention. Results: For data analysis, we used multiple-variable covariance. The findings showed the effect of treatment (p<0. 05) on life satisfaction in the post-test, as well as on positive and aggressive attitudes in the post-test and follow-up stages. Conclusions: According to the results, patients with spinal cord injury can benefit from treatment aimed at improving their quality of life, leading to improved life satisfaction and positive affect, as well as a reduction in their aggressiveness.