To determine optimal irrigation management and crop yield, the use of simulation models is an appropriate tool. AquaCrop is one of the practical models used for simulating yield variations under different water and soil management scenarios. This study investigates the interactive effects of salinity and water stress, as well as the utilization of drainage water irrigation, on the yield of quinoa and to simulate it using the AquaCrop model in an experimental field in the Faculty of Water and Environmental Engineering of Shahid Chamran University of Ahvaz in 2022-2023. This experiment was based on a system of split-plot experiment with a randomized, complete block design with three replications. The four salinity levels tested were 2, 10, 15, and 20 dS/m, and three irrigation regimes used were full irrigation, 80% of crop water requirement, and 60% of crop water requirement . The results indicated that the highest and lowest grain yields were 5.45 and 1.8 t/ha in autumn and 3.87 and 0.73 t/ha in spring, respectively, in treatments S1I1 and S4I3 .Various statistical analysis showed that the AquaCrop model had an acceptable accuracy in simulating quinoa yield, with NRMSE values less than 0.2 during the calibration phase. The statistical indices EF, R2, and d during the model validation phase (0.70, 0.88, and 0.97 in autumn and 0.74, 0.85, and 0.97 in spring) approached one, indicating adequate model accuracy in simulating grain yield. However, the model's accuracy in simulating grain yield during autumn in the validation phase with NRMSE, EF, R2, and d values of 0.18, 0.75, 0.74, and 0.83, respectively, was lower than its accuracy in simulating grain yield during spring seasons. Overall, the AquaCrop model exhibited acceptable accuracy in simulating quinoa yield under salinity and water stress conditions.