Dear Editor-in-Chief: Helicobacter pylori infection is the most frequently seen infection worldwide. It is the most widely seen agent of gastrointestinal disease, primarily gastric disease. It causes also a wide spectrum of extra-gastrointestinal disorders. Cancer, lymphoma, cardiovascular disease, dermatological dis-ease, liver and gallbladder diseases, anemia, diabetes mellitus, autoimmune disease, atopy, asthma, neurological disease, growth, failure to thrive, bone disease, and micronutrient deficiency could be associated with H. pylori infection, as has been suggested in literature, especially in the adults.