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Information Journal Paper

Title

COMBINATION EFFECT OF GSTM1, GSTT1 AND GSTP1 POLYMORPHISMS AND RISK OF SYSTEMIC LUPUS ERYTHEMATOSUS

Pages

  814-821

Abstract

 Background: Progression of SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) could be due to oxidative stress especially through reactive oxygen species (ROS). Detoxification of ROS is largely performed by GLUTATHIONE S-TRANSFERASEs (GSTs), therefore POLYMORPHISMs of GSTM1, GSTT1 and GSTP1 GENEs which decrease enzymes activity could affect SLE susceptibility. The aim of this study was to determine the effects of GSTM1 (deletion), GSTT1 (deletion) and GSTP1 (Ile105Val) POLYMORPHISMs on SLE susceptibility.Methods: Genomic DNA was extracted from blood samples of 163 SLE patients and 180 age, sex and ethnically matched controls. GSTs genotypes were determined by polymerase chain reaction (PCR) -multiplex procedure or polymerase chain reaction-restriction fragment length POLYMORPHISM (PCR-RFLP) analysis.Results: GSTT1 null genotype frequency was higher in SLE patients than controls. NO association observed between GSTM1 null genotype or GSTP1 Ile105Val POLYMORPHISM with SLE. Nevertheless combination of GSTT1 null/ GSTM1 null genotypes showed 2.8-fold increase in risk of SLE. Moreover the combination of GSTT1 null/ GSTM1 null/GSTP1 Ile/Val and Val/Val genotypes increased the SLE risk about 8 fold.Conclusion: Present data suggest that GSTT1 null/ GSTM1 null/GSTP1 Ile/Val and Val/Val genotypes might largely contribute to the pathogenesis of SLE.

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    APA: Copy

    SALIMI, SAEEDEH, NAKHAEE, ALIREZA, JAFARI, MEHDI, JAHANTIGH, DANIAL, SANDOOGHI, MAHNAZ, ZAKERI, ZAHRA, SHAHRAKIPOUR, MAHNAZ, NAGHAVI, ANOOSH, & FARAJIAN MASHHADI, FARZANEH. (2015). COMBINATION EFFECT OF GSTM1, GSTT1 AND GSTP1 POLYMORPHISMS AND RISK OF SYSTEMIC LUPUS ERYTHEMATOSUS. IRANIAN JOURNAL OF PUBLIC HEALTH, 44(6), 814-821. SID. https://sid.ir/paper/273939/en

    Vancouver: Copy

    SALIMI SAEEDEH, NAKHAEE ALIREZA, JAFARI MEHDI, JAHANTIGH DANIAL, SANDOOGHI MAHNAZ, ZAKERI ZAHRA, SHAHRAKIPOUR MAHNAZ, NAGHAVI ANOOSH, FARAJIAN MASHHADI FARZANEH. COMBINATION EFFECT OF GSTM1, GSTT1 AND GSTP1 POLYMORPHISMS AND RISK OF SYSTEMIC LUPUS ERYTHEMATOSUS. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2015;44(6):814-821. Available from: https://sid.ir/paper/273939/en

    IEEE: Copy

    SAEEDEH SALIMI, ALIREZA NAKHAEE, MEHDI JAFARI, DANIAL JAHANTIGH, MAHNAZ SANDOOGHI, ZAHRA ZAKERI, MAHNAZ SHAHRAKIPOUR, ANOOSH NAGHAVI, and FARZANEH FARAJIAN MASHHADI, “COMBINATION EFFECT OF GSTM1, GSTT1 AND GSTP1 POLYMORPHISMS AND RISK OF SYSTEMIC LUPUS ERYTHEMATOSUS,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 44, no. 6, pp. 814–821, 2015, [Online]. Available: https://sid.ir/paper/273939/en

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