Providing and distributing the medicine as a strategic production is affected by variouse factors such as import, internal production, distribution, currency affairs, forms of consuming, ... and so on. In general it plays an important role in health economy of society.Parallel to other problems, rational prescribing and uses of medicine is one of the most important difficulties in medical sciences, This problem not only makes the real medication immposible by increasing the side-effects, but also entail the increase of economical loss, inappropriate distribution and shortage of neccessary drugs, Variouse patterns of irrational prescribing have been shown in different studies, in different countries. All of the studies in Iran Proved the irrational pattern of drug prescription, which containes a reasonable percent of the cases.Education plus improvement of the knowledge in this realm leads to changing in attitude and performance. Reviewing the effect of education has a signifcant effect in prescription of the doctors. CME as a component of education is directly involved with medical community and thus has an outstanding influences here. CME is generally involved with improvment of Knowledge, attitude and performance, which effects directly or indirecrly on the rational prescribing of medicine. Paying special attention to the programmes about pharmaceutical education and rational use of drugs from 1374 to 1378 (1991-1999), shows a reasomablly higer trends including: 2 seminars in 1374 increased to 17 in 1378 (%63 pharmaceutical seminars in 1378), - Conferences about rational prescribing of drugs contained in average %7 of pharmaceutical conferences.- Short Periods programmes are %15 of the all programmes.- Pharmaceutical workshops shows %100 increase relative to the years 1370-1377 (1991-1999), which %50 was directly about rational prescribing.- %4 of composed programmes for GPs, and %5 of total composed pharmaceutical programmes were about rational prescribing. Altough education of rational prescribing of medicine from 1374 to 1378 had an increasing improvement, but still, parallele to dept. of CME it demand more attempts for improvement of quality of the actions by scientific groups.