The operation of fixed activated sludge system for treatment of wastewater containing heavy metal compounds (chromium, lead and nickel), by using of fixed activated sludge (FAS) system is studied in this research. A Plexiglas tank consisted of three sections including a downward-flow aerated reactor, an upward-flow aerated reactor and a gravity sediment unit, fed with the synthetic wastewater. The results showed that COD removal efficiency in the FAS is about 96% and the acclimation time for microorganisms is short. While chromium, lead and nickel removal efficiency in the fixed activated sludge at concentration of 1 mg/lit is 84%, 75% and 80%, respectively, by increasing concentration of them to 5 mg/lit, the removal percentage increased to 90%,84% and 87%, respectively. When concentration of chromium, lead and nickel increased to 10 mg/lit, the removal efficiency became 85%, 95% and 92%, respectively. Concentration of heavy metals (chromium, lead and nickel) at 50 mg/lit; caused the removal efficiency of 86%, 96% and 95.1%, respectively….