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Introduction: It is felt that there is an information void
regarding the effect of macronutrients on
cardiovascular responses such as cardiac output, heart rate,stroke
volume,systolic blood
pressure,diastolic blood pressure and mean arterial pressure, therefore, this
study was designed to
explore these effects at Shaheed Beheshti University in 2001.
Materials & Methods: This clinical trial was carried out on 10 healthy subjects
and 15 type 2
diabetics. Cardiovascular responses defined before and 15,30,60,90 and 120
minutes after the intake of
wheat starch,sodium caseinat and olive oil. The calorie level was 10 kcal per kg
of ideal body weight.
Sttatistical analyses were done by analysis of variance with repeated measures,
independent - t test and
dcpendent- t test.
Results: The age of healthy subjects (4 women ,6men)was 36.6±5.8(mean±SD)yr,bodymass
index was
.H1.2Kg/m2 , age for the type 2 diabetics (4 women ,11men)was 38.9±5.2(mean±SD)yr
, body mass
index was 24±1.6Kg/m2. In healthy subjects,
macronutrients caused marked and gradually developing
postprandial increases in cardiac output, while in type 2 diabetics,cardiac
output had no changes. In
healthy subjects, systolic blood pressure and mean arterial pressure rose after
the ingestion of
maclonutrients (P<0.05). In type 2 diabetics after the ingestion of
macronutrients there was a fall in
systolic blood pressure and mean arterial pressure(P<0.05).In both groups,
diastolic blood pressure
showed no changes.
Conclusion: There were considerable differences in the speed of development and
the pattern of the
cardiovascular responses between type 2 diabetics and healthy subjects
(P<0.05).Finally we conclude
that diabetes in the early stages probably involves the cardiovascular system.