US foreign policy toward Iran after the Islamic Revolution has had an adversarial approach and has been under the influence of centers of power against the normalization of ties between the two countries. Pro-Israel lobbies, without doubt, play an important role in adversely affecting US-Iran relations. Yet, Arab lobbies supported by some countries in the Middle East try to intensify the hostility between the US and Iran. The main question this paper tries to answer is “ How Arab lobbies influence US foreign policy against Iran? ” It’ s assumed that portraying Iran’ s power to be destructive to Middle East stability in order to intensify Iran-phobia and influence US foreign policy against Iran is the strategy these lobbies pursue. Arab lobbies have partly succeeded in achieving their goals, but the development in the Middle East and the future of energy (especially oil) cause the long-term outlook of these lobbies to be unclear. Using descriptive-interpretive this paper tries to analyze the main components in Arab lobbying and the reasons for the weakening of their role based on current developments and strategic foresight.