Background & Objective: Using internet have had a significant impact on the lifestyle changes of internet clients which can affect their health. The aim of this study was to survey the relationship between lifestyle related to internet with loneliness and social support of the internet clients in Ilam University of medical sciences.Methods: This study was a cross sectional study which was performed in 2014 on 400 university students and personnel of Ilam University of medical sciences using stratified random sampling method. Data collection instrument was a questionnaire comprising of four sections: demographic information, lifestyle related to internet questionnaire , loneliness and social supports questionnaires. All data were analyzed using SPSS software by Mann Withney and Kruscall- Wallis tests and linear regression test.Results: The linear regression results showed that there was a significant relationship between loneliness and lifestyle related to the internet, gender, marital status, occupational statues and age (P<0.01). There was also a significant relationship between social support and lifestyle related to the internet and age (P<0.05). The results showed that there was a significant relationship between loneliness and social support with marital status, educational degree and internet usage (P<0.01).Conclusion: According to the significant relation between loneliness and social support with the lifestyle related to the internet, and regarding the inevitability of Internet, it seems more supporting the students and implementing the educational programs for university clients about suitable using of internet is necessary.